Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM049QO)

Drug Name

4-Morpholin-2-yl-benzene-1,2-diol Drug Info

Synonyms

4-(2-Morpholinyl)pyrocatechol; 1,2-Benzenediol, 4-(2-morpholinyl)-; BRN 0170116; Pyrocatechol, 4-(2-morpholinyl)-; CHEMBL7681; 54826-84-5; 2-(3,4-Dioxyphenyl)tetrahydro-1,4-oxazin [German]; 4-Morpholin-2-yl-benzene-1,2-diol; AC1MIECG; 2-(3,4-Dioxyphenyl)tetrahydro-1,4-oxazin; 3,4-Dioxyphenyl-Morpholin; SCHEMBL17632965; CTK5A2632; 4-morpholin-2-ylbenzene-1,2-diol; BDBM50000502; AKOS022644999; UK-42620; LS-136459

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3042920
CAS Number: CAS 54826-84-5
TTD Drug ID: DM049QO

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1B (ADRA1B)	TTBRKXS	ADA1B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	3.154	3.853	4.129	2.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	9.43E-01	-0.03	-0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic rece... J Med Chem. 1992 Mar 20;35(6):1009-18.