Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0N68L)

Drug Name

8-(3-Nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline Drug Info

Synonyms

8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline; 159925-31-2; RS-14203; CHEMBL127944; 8-(3-Nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline; 8-(3-nitrophenyl)-6-(4-pyridinylmethyl)Quinoline; ZINC6165; SCHEMBL3698956; DTXSID20431317; XRSKAWJXBDACRF-UHFFFAOYSA-N; 3g58; 3g45; BDBM50092632; AKOS022171718; 4CA-1115; KB-74213; DA-09714; AJ-08271; AX8257760; FT-0733089

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9819356
CAS Number: CAS 159925-31-2
TTD Drug ID: DM0N68L

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 4A (PDE4A)	TTZ97H5	PDE4A_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phosphodiesterase 4A (PDE4A)	DTT	PDE4A	4.1	2.787	2.379	3.433

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 4A (PDE4A)	DTT	PDE4A	9.26E-01	-3.01E-03	-0.01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl... J Med Chem. 2000 Oct 19;43(21):3820-3.