Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0SOKJ)

Drug Name

Imidazole benzamide derivative 1 Drug Info

Synonyms

PMID28627961-Compound-21

Indication

Disease Entry	ICD 11	Status	REF
Knee pain	ME82	Patented	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin E synthase (PTGES)	TTYLQ8V	PTGES_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin E synthase (PTGES)	DTT	PTGES	4.289	5.498	5.489	5.794

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Knee pain

ICD Disease Classification

ME82

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin E synthase (PTGES)	DTT	PTGES	7.92E-02	-0.05	-0.24

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059.