Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM17TIX)

Drug Name

1-Benzyl-1,2-dihydro-indazol-3-one Drug Info

Synonyms

1-Benzyl-3-hydroxy-1H-indazole; 2215-63-6; 1-Benzyl-1H-indazol-3-ol; 1-Benzyl-1,2-dihydro-3H-indazol-3-one; 1-benzyl-2H-indazol-3-one; 1-Benzyl-1,2-dihydro-indazol-3-one; 1-benzylindazol-3-ol; CHEMBL8612; SXPJFDSMKWLOAB-UHFFFAOYSA-N; 3H-Indazol-3-one, 1,2-dihydro-1-(phenylmethyl)-; 1-Benzyl-2,3-dihydroindazol-3-one; CBMicro_007258; EINECS 218-680-4; 5-Hydroxybenzydamine; AC1Q6GZH; ACMC-1CR7T; ChemDiv2_000492; 1-Benzyl-3-hydroxyindazole; AC1Q6K7E; AC1L2O7R; Oprea1_591436; Oprea1_122894; MLS001211149; SCHEMBL376005

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 75181
CAS Number: CAS 2215-63-6
TTD Drug ID: DM17TIX

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36.