Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM19KY6)

Drug Name

ADC-7828 Drug Info

Synonyms

Neutrophil elastase inhibitors (inhaled, CF/COPD); Neutrophil elastase inhibitor (inhaled, cystic fibrosis/chronic obstructive pulmonary disease), Argenta; Neutrophil elastase inhibitors (inhaled, CF/COPD), Argenta; Neutrophil elastase inhibitors (inhaled, CF/COPD), Pulmagen

Indication

Disease Entry	ICD 11	Status	REF
Chronic obstructive pulmonary disease	CA22	Investigative	[1]

Cross-matching ID

TTD Drug ID: DM19KY6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neutrophil elastase (NE)	TTPLTSQ	ELNE_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neutrophil elastase (NE)	DTT	ELANE	2.379	2.036	1.379	2.945

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Chronic obstructive pulmonary disease

ICD Disease Classification

CA22

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neutrophil elastase (NE)	DTT	ELANE	2.35E-01	-0.55	-0.82

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2358).