Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1F53L)

Drug Name

Indol-1-yl-pyridin-4-yl-amine Drug Info

Synonyms

119257-33-9; N-(4-pyridinyl)-1H-indol-1-amine; N-(PYRIDIN-4-YL)-1H-INDOL-1-AMINE; CHEMBL154488; 1H-Indol-1-amine,N-4-pyridinyl-; N-pyridin-4-ylindol-1-amine; N-4-Pyridinyl-1H-indol-1-amine; AC1MIWH0; ACMC-1C0H7; SCHEMBL3139425; ZINC24994; CTK4B1164; DTXSID90152360; YFXZWVUZIPQSKX-UHFFFAOYSA-N; BDBM50048608; 1H-Indol-1-amine, N-4-pyridinyl-; AKOS015924421; RP26505; KB-139314; J-523178

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3081186
CAS Number: CAS 119257-33-9
TTD Drug ID: DM1F53L

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81.