Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1GBX8)

Drug Name
(S)-2-amino-3-cyclohexylpropanoic acid Drug Info
Synonyms
27527-05-5; (S)-2-amino-3-cyclohexylpropanoic acid; L-Cyclohexylalanine; H-Cha-OH; (2S)-2-amino-3-cyclohexylpropanoic acid; 3-Cyclohexyl-L-alanine; L-3-Cyclohexylalanine; (S)-2-Amino-3-cyclohexylpropionic acid; BETA-CYCLOHEXYL-ALANINE; L-beta-Cyclohexylalanine; UNII-GYR4SF0FVQ; GYR4SF0FVQ; CHEMBL383208; Cyclohexanepropanoic acid, alpha-amino-, (alphaS)-; 2-AMINO-3-CYCLOHEXYL-PROPIONIC ACID; 3-cyclohexylalanine; b-cyclohexyl alanine; beta-cyclohexylalanine; PubChem5760; beta-cyclohexyl alanine; AC1LEHTM; AC1Q5QKA
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
712421
CAS Number
CAS 27527-05-5
TTD Drug ID
DM1GBX8

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 5.083 4.833 5.343 2.536
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 9.36E-01 -0.03 -0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 2.81E-05 -0.15 -0.68
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.