Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1GRCU)

Drug Name
JNJ-17216498 Drug Info
Synonyms Histamine H3 antagonist (oral, narcolepsy) J&J
Indication
Disease Entry ICD 11 Status REF
Narcolepsy 7A20 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM1GRCU

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H3 receptor (H3R) TT9JNIC HRH3_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Histamine H3 receptor (H3R) DTT HRH3 3.225 3.399 3.17 3.027
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Narcolepsy
ICD Disease Classification 7A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histamine H3 receptor (H3R) DTT HRH3 3.62E-02 -0.09 -0.22
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00424931) A Safety and Effectiveness Study of a Single Dose of JNJ-17216498 in Patients With Narcolepsy. U.S. National Institutes of Health.
2 Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.