Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1JCW8)

Drug Name

Xaliproden Drug Info

Synonyms

Xaliproden (USAN); 1,2,3,6-tetrahydro-1-(2-(2-naphthalenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)-pyridine; 1,2,3,6-tetrahydro-1-(2-(2-naphthyl)ethyl)-4-(alpha,alpha,alpha-trifluoro-m-tolyl)pyridine; 1-(2-(2-Naphthyl)ethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine; 1-(2-naphthalen-2-ylethyl)-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine; 1-[2-(2-naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Indication

Disease Entry	ICD 11	Status	REF
Juvenile idiopathic arthritis	FA24	Phase 3	[1]
Plaque psoriasis	EA90.0	Phase 3	[1]
Alzheimer disease	8A20	Discontinued in Phase 3	[2]
Lateral sclerosis	8B61	Discontinued in Phase 3	[2]
Peripheral sensory neuropathies	LD27.3	Discontinued in Phase 3	[2]

Cross-matching ID

PubChem CID: 128919
ChEBI ID: CHEBI:48520
CAS Number: CAS 135354-02-8
TTD Drug ID: DM1JCW8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Antagonist	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Juvenile idiopathic arthritis

ICD Disease Classification

FA24

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	7.48E-01	-1.45E-04	-5.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001601)
3	Pharma & Vaccines. Product Development Pipeline. April 29 2009.