Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1NVEI)

Drug Name

4,4'-(ethane-1,2-diyl)dibenzene-1,3-diol Drug Info

Synonyms

CHEMBL499124; SCHEMBL1397158; GTPL8785; Bibenzyl-2,2',4,4'-tetraol; BDBM50263336; compound 7 [PMID: 21334791]; 4,4''-(ethane-1,2-diyl)dibenzene-1,3-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 24849532
TTD Drug ID: DM1NVEI

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosinase (TYR)	DTT	TYR	5.959	5.711	5.973	4.912

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	6.68E-04	2.54	1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Molecular design of potent tyrosinase inhibitors having the bibenzyl skeleton. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5252-4.