Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTULVH8)

DTT Name Tyrosinase (TYR)
Synonyms Tumor rejection antigen AB; SK29-AB; Monophenol monooxygenase; LB24-AB
Gene Name TYR
DTT Type
Successful target
 [1]
BioChemical Class
Paired donor oxygen oxidoreductase
UniProt ID
TYRO_HUMAN
TTD ID
T97035
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 1.14.18.1
Sequence
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
Function
Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
KEGG Pathway
Tyrosine metabolism (hsa00350 )
Riboflavin metabolism (hsa00740 )
Metabolic pathways (hsa01100 )
Melanogenesis (hsa04916 )
Reactome Pathway
Melanin biosynthesis (R-HSA-5662702 )
BioCyc Pathway
MetaCyc:HS01248-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1]
Monobenzone DMVJS2K Vitiligo ED63.0 Approved [1]
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5 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Melanoma vaccine DMQEC6Z Melanoma 2C30 Phase 3 [2]
Multi-epitope peptide melanoma vaccine DMZPEHY Melanoma 2C30 Phase 3 [3]
MKC-1106-MT DMXKOW6 Melanoma 2C30 Phase 2 [4]
Multi-epitope tyrosinase/gp100 vaccine DMN68ZL Melanoma 2C30 Phase 2 [5]
Polynoma-1 DM3QDA6 Melanoma 2C30 Phase 2 [6]
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135 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
3-(phenoxymethyl) benzylamine derivative 1 DM9YJWU Albinism EC23.2 Patented [7]
3-(phenoxymethyl) benzylamine derivative 2 DMGN9IX Albinism EC23.2 Patented [7]
3-(phenoxymethyl) benzylamine derivative 3 DM43EKN Albinism EC23.2 Patented [7]
3-(phenoxymethyl) benzylamine derivative 4 DM58X6N Albinism EC23.2 Patented [7]
3-(phenoxymethyl) benzylamine derivative 5 DM84HG2 Albinism EC23.2 Patented [7]
3-(phenoxymethyl) benzylamine derivative 6 DM0WBM3 Albinism EC23.2 Patented [7]
Aromatic hydrazine carboxyimidoamide derivative 1 DMJ8X7A Albinism EC23.2 Patented [7]
Aromatic hydrazine carboxyimidoamide derivative 2 DMYH4D1 Albinism EC23.2 Patented [7]
Aromatic hydrazine carboxyimidoamide derivative 3 DML63B7 Albinism EC23.2 Patented [7]
Aromatic hydrazine carboxyimidoamide derivative 4 DMKE5PB Albinism EC23.2 Patented [7]
Aromatic hydrazine carboxyimidoamide derivative 5 DM4AM1E Albinism EC23.2 Patented [7]
Aromatic hydrazine carboxyimidoamide derivative 6 DM8HDQT Albinism EC23.2 Patented [7]
Benzimidazole derivative 3 DMY93WG Albinism EC23.2 Patented [7]
Benzimidazole derivative 4 DM9PL3F Albinism EC23.2 Patented [7]
Benzoic acid linked peptide analog 1 DMND8R0 Albinism EC23.2 Patented [7]
Benzoic acid linked peptide analog 2 DMUBG20 Albinism EC23.2 Patented [7]
Benzoic acid linked peptide analog 3 DM42BU9 Albinism EC23.2 Patented [7]
Benzoic acid linked peptide analog 4 DMNX5EU Albinism EC23.2 Patented [7]
Benzoic acid linked peptide analog 5 DMNIZAR Albinism EC23.2 Patented [7]
Benzoic acid linked peptide analog 6 DMTHKES Albinism EC23.2 Patented [7]
Benzothiazole analog 1 DMHXFCQ Albinism EC23.2 Patented [7]
Benzothiazole analog 2 DMUKNXF Albinism EC23.2 Patented [7]
Benzothiazole analog 3 DMDLY38 Albinism EC23.2 Patented [7]
Benzothiazole analog 4 DMNDAT0 Albinism EC23.2 Patented [7]
Benzothiazole analog 5 DMN1J09 Albinism EC23.2 Patented [7]
Benzothiazoline derivative 1 DMJDC5T Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 1 DM79WI1 Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 10 DMRXMCH Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 11 DMVPR1D Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 12 DMOHBCN Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 13 DMKDBQG Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 14 DMWUAXM Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 2 DMAEQ0I Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 3 DMGV8T9 Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 4 DMNQF9S Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 5 DMBC48K Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 6 DMK9XV8 Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 7 DMES41R Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 8 DMRIPVG Albinism EC23.2 Patented [7]
Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 9 DM7U20W Albinism EC23.2 Patented [7]
Cyclohexyl carbamate derivative 1 DMORFPT Albinism EC23.2 Patented [7]
Cyclohexyl carbamate derivative 2 DM6VPIR Albinism EC23.2 Patented [7]
Cyclohexyl carbamate derivative 3 DMVIZTY Albinism EC23.2 Patented [7]
Cyclohexyl carbamate derivative 4 DMLD49W Albinism EC23.2 Patented [7]
Cyclohexyl carbamate derivative 5 DMS68DP Albinism EC23.2 Patented [7]
Cyclohexyl carbamate derivative 6 DMSD2TN Albinism EC23.2 Patented [7]
Cyclohexyl carbamate derivative 7 DM2URPE Albinism EC23.2 Patented [7]
Cyclohexyl carbamate derivative 8 DMB9DEO Albinism EC23.2 Patented [7]
Diamine derivative 1 DMUG69Q Albinism EC23.2 Patented [7]
Diamine derivative 2 DMQEYTJ Albinism EC23.2 Patented [7]
Diamine derivative 3 DMSYX4U Albinism EC23.2 Patented [7]
Dihydroxyfumaric acid derivative 1 DMAH1EP Albinism EC23.2 Patented [7]
Monoamine derivative 1 DMRWNAY Albinism EC23.2 Patented [7]
Monoamine derivative 2 DMAZ6DI Albinism EC23.2 Patented [7]
Monoamine derivative 3 DM4I75L Albinism EC23.2 Patented [7]
Monoamine derivative 4 DMYFKP2 Albinism EC23.2 Patented [7]
Monoamine derivative 5 DM3PF60 Albinism EC23.2 Patented [7]
Nicotinyl hydroxamic acid derivative 1 DMW2LD5 Albinism EC23.2 Patented [7]
P-coumaric acid derivative 1 DM231WS Albinism EC23.2 Patented [7]
P-coumaric acid derivative 2 DMFTZBY Albinism EC23.2 Patented [7]
P-coumaric acid derivative 3 DMFE4IY Albinism EC23.2 Patented [7]
P-coumaric acid derivative 4 DM5WQP3 Albinism EC23.2 Patented [7]
P-coumaric acid derivative 5 DMFKGZ7 Albinism EC23.2 Patented [7]
P-coumaric acid derivative 6 DMF4YGC Albinism EC23.2 Patented [7]
PMID26815044-Compound-114 DMOJ936 Albinism EC23.2 Patented [7]
PMID26815044-Compound-115 DM8SWHO Albinism EC23.2 Patented [7]
PMID26815044-Compound-116 DMDUXRT Albinism EC23.2 Patented [7]
PMID26815044-Compound-117 DM2GON6 Albinism EC23.2 Patented [7]
PMID26815044-Compound-118 DMC28VB Albinism EC23.2 Patented [7]
PMID26815044-Compound-121 DMMNXA1 Albinism EC23.2 Patented [7]
PMID26815044-Compound-122 DM1HAGJ Albinism EC23.2 Patented [7]
PMID26815044-Compound-123 DMFTE3Y Albinism EC23.2 Patented [7]
PMID26815044-Compound-124 DM25WGP Albinism EC23.2 Patented [7]
PMID26815044-Compound-125 DM6EFIN Albinism EC23.2 Patented [7]
PMID26815044-Compound-126 DMMJK0L Albinism EC23.2 Patented [7]
PMID26815044-Compound-127 DMO97LR Albinism EC23.2 Patented [7]
PMID26815044-Compound-30 DMH8E7S Albinism EC23.2 Patented [7]
PMID26815044-Compound-31 DMBINQ9 Albinism EC23.2 Patented [7]
PMID26815044-Compound-32 DMN5H3C Albinism EC23.2 Patented [7]
PMID26815044-Compound-47 DMM3FJO Albinism EC23.2 Patented [7]
PMID26815044-Compound-48 DMJ1Z7U Albinism EC23.2 Patented [7]
PMID26815044-Compound-49 DMD9WRS Albinism EC23.2 Patented [7]
PMID26815044-Compound-50 DMYI1SX Albinism EC23.2 Patented [7]
PMID26815044-Compound-51 DMQGTJ5 Albinism EC23.2 Patented [7]
PMID26815044-Compound-52 DMN4C2O Albinism EC23.2 Patented [7]
PMID26815044-Compound-64 DMEKBOG Albinism EC23.2 Patented [7]
PMID26815044-Compound-93 DMV46DG Albinism EC23.2 Patented [7]
PMID26815044-Compound-H DMI3QLT Albinism EC23.2 Patented [7]
PMID26815044-Compound-I DMZISDR Albinism EC23.2 Patented [7]
PMID29130358-Compound-Figure11(3) DMSME2B N. A. N. A. Patented [8]
Polyhydroxy benzamide derivative 1 DMPHCJ5 Albinism EC23.2 Patented [7]
Polyhydroxy benzamide derivative 2 DM0BRNU Albinism EC23.2 Patented [7]
Polyhydroxy benzamide derivative 3 DMCLZWS Albinism EC23.2 Patented [7]
Polyhydroxy benzamide derivative 4 DM6QBV2 Albinism EC23.2 Patented [7]
Polyhydroxy benzamide derivative 5 DMZC6AI Albinism EC23.2 Patented [7]
Resorcinol compound 1 DMG4FYP Albinism EC23.2 Patented [7]
Resorcinol compound 10 DMPA26U Albinism EC23.2 Patented [7]
Resorcinol compound 11 DMGDLPZ Albinism EC23.2 Patented [7]
Resorcinol compound 12 DMEMT3I Albinism EC23.2 Patented [7]
Resorcinol compound 13 DMVARUE Albinism EC23.2 Patented [7]
Resorcinol compound 14 DM6XFA5 Albinism EC23.2 Patented [7]
Resorcinol compound 15 DMSLYVT Albinism EC23.2 Patented [7]
Resorcinol compound 16 DMFDXBJ Albinism EC23.2 Patented [7]
Resorcinol compound 17 DMFR4S0 Albinism EC23.2 Patented [7]
Resorcinol compound 18 DM64R2K Albinism EC23.2 Patented [7]
Resorcinol compound 19 DMJIZPQ Albinism EC23.2 Patented [7]
Resorcinol compound 2 DMGDQYW Albinism EC23.2 Patented [7]
Resorcinol compound 20 DME4OGJ Albinism EC23.2 Patented [7]
Resorcinol compound 21 DM8EQPJ Albinism EC23.2 Patented [7]
Resorcinol compound 22 DMSW3GB Albinism EC23.2 Patented [7]
Resorcinol compound 23 DMU3APC Albinism EC23.2 Patented [7]
Resorcinol compound 24 DM2IKDL Albinism EC23.2 Patented [7]
Resorcinol compound 25 DMEZUN7 Albinism EC23.2 Patented [7]
Resorcinol compound 26 DMT21JG Albinism EC23.2 Patented [7]
Resorcinol compound 27 DM71R3T Albinism EC23.2 Patented [7]
Resorcinol compound 28 DMCHLAN Albinism EC23.2 Patented [7]
Resorcinol compound 29 DML7ONU Albinism EC23.2 Patented [7]
Resorcinol compound 3 DMPTK0G Albinism EC23.2 Patented [7]
Resorcinol compound 30 DMMTVN4 Albinism EC23.2 Patented [7]
Resorcinol compound 31 DMSPCLD Albinism EC23.2 Patented [7]
Resorcinol compound 32 DM2RPYB Albinism EC23.2 Patented [7]
Resorcinol compound 33 DMLJYS1 Albinism EC23.2 Patented [7]
Resorcinol compound 34 DMQF90E Albinism EC23.2 Patented [7]
Resorcinol compound 4 DMIM9EY Albinism EC23.2 Patented [7]
Resorcinol compound 5 DMQ5TYK Albinism EC23.2 Patented [7]
Resorcinol compound 6 DM809YH Albinism EC23.2 Patented [7]
Resorcinol compound 7 DM031RU Albinism EC23.2 Patented [7]
Resorcinol compound 8 DMLF53V Albinism EC23.2 Patented [7]
Resorcinol compound 9 DMCJO0R Albinism EC23.2 Patented [7]
Thiazole derivative 1 DM2WDXV Albinism EC23.2 Patented [7]
Thiazolidine derivative 1 DM05VO6 Albinism EC23.2 Patented [7]
Thiazolidine derivative 2 DM73GNJ Albinism EC23.2 Patented [7]
Thiazolidine derivative 3 DMXFGTZ Albinism EC23.2 Patented [7]
Thiazoline derivative 1 DM86HU3 Albinism EC23.2 Patented [7]
Thiazoline derivative 2 DMXRE1V Albinism EC23.2 Patented [7]
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⏷ Show the Full List of 135 Patented Agent(s)
102 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+/-)-Daedalin A DMBSH5L Discovery agent N.A. Investigative [9]
1'-(4-Methyl-benzyl)-[1,4']bipiperidinyl DMNDJTL Discovery agent N.A. Investigative [10]
1-(1,4-diacetylphenyl)dithiosemicarbazide DMHNOLA Discovery agent N.A. Investigative [11]
1-(1-(4-bromophenyl)ethylidene)thiosemicarbazide DMXJ58Z Discovery agent N.A. Investigative [11]
1-(1-(4-fluorophenyl)ethylidene)thiosemicarbazide DMQBHGK Discovery agent N.A. Investigative [11]
1-(1-(pyrazin-2-yl)ethylidene)thiosemicarbazide DM7WJOY Discovery agent N.A. Investigative [11]
1-(1-(pyridin-3-yl)ethylidene)thiosemicarbazide DMJ21XT Discovery agent N.A. Investigative [11]
1-(1-(thiophen-2-yl)ethylidene)thiosemicarbazide DMQSEF6 Discovery agent N.A. Investigative [11]
1-(1-p-tolylethylidene)thiosemicarbazide DM2PQFE Discovery agent N.A. Investigative [11]
1-(1-phenylethylidene)thiosemicarbazide DMN5SL6 Discovery agent N.A. Investigative [11]
1-(2,5-Dimethyl-1H-pyrrol-1-yl)thiourea DM3FHJK Discovery agent N.A. Investigative [12]
1-(3-Methylbutylidene)thiosemicarbazide DMI15LJ Discovery agent N.A. Investigative [12]
1-(3-Oxocyclohexylidene)thiosemicarbazide DMEMHIF Discovery agent N.A. Investigative [12]
1-(3-phenoxypropyl)-4-(piperidin-1-yl)piperidine DMG8DLM Discovery agent N.A. Investigative [10]
1-(3-Phenylallylidene)thiosemicarbazide DMFPUGV Discovery agent N.A. Investigative [12]
1-(4-(benzyloxy)phenyl)-3-hydroxyurea DM7FWK8 Discovery agent N.A. Investigative [13]
1-(4-bromophenyl)-3-hydroxyurea DMEUHDL Discovery agent N.A. Investigative [13]
1-(4-Methylpent-3-en-2-ylidene)thiosemicarbazide DM3NVLB Discovery agent N.A. Investigative [12]
1-(But-2-enylidene)thiosemicarbazide DMEULBF Discovery agent N.A. Investigative [12]
1-(Butan-2-ylidene)thiosemicarbazide DMXU1EF Discovery agent N.A. Investigative [12]
1-(Propan-2-ylidene)thiosemicarbazide DMO10FD Discovery agent N.A. Investigative [12]
1-Cyclohexylidenethiosemicarbazide DM7A50Z Discovery agent N.A. Investigative [12]
1-Cyclopentylidenethiosemicarbazide DMDGWAY Discovery agent N.A. Investigative [12]
1-Ethylidenethiosemicarbazide DMQRKZO Discovery agent N.A. Investigative [12]
1-hydroxy-3-(4-(trifluoromethyl)phenyl)urea DMGNVEF Discovery agent N.A. Investigative [13]
1-hydroxy-3-(4-nitrophenyl)urea DMZ7GUP Discovery agent N.A. Investigative [13]
1-hydroxy-3-phenylurea DM4TSVC Discovery agent N.A. Investigative [13]
1-Propylidenethiosemicarbazide DMXOUFI Discovery agent N.A. Investigative [12]
2,2',4,4',6'-pentahydroxychalcone DMAYXUR Discovery agent N.A. Investigative [14]
2,2',4,4'-tetrahydroxy-6'-methoxychalcone DMMJ613 Discovery agent N.A. Investigative [14]
2,2',4,4'-tetrahydroxychalcone DMM6KBD Discovery agent N.A. Investigative [14]
2,2'-bi(1,3,4-thiadiazole)-5,5'(4H,4'H)-dithione DMPMOHQ Discovery agent N.A. Investigative [15]
2,4,3',5'-tetrahydroxybibenzyl DMI2PY7 Discovery agent N.A. Investigative [16]
2-(butylthiomethyl)-5-hydroxy-4H-pyran-4-one DMFO7CH Discovery agent N.A. Investigative [17]
2-(cyclohexylthiomethyl)-5-hydroxy-4H-pyran-4-one DM2CAI1 Discovery agent N.A. Investigative [17]
2-(ethylthiomethyl)-5-hydroxy-4H-pyran-4-one DM8GJCU Discovery agent N.A. Investigative [17]
2-(heptylthiomethyl)-5-hydroxy-4H-pyran-4-one DM490BL Discovery agent N.A. Investigative [17]
2-(hexylthiomethyl)-5-hydroxy-4H-pyran-4-one DM235Q4 Discovery agent N.A. Investigative [17]
2-hydroxy-3-isopropyl-2,4,6-cycloheptatrien-1-one DMK8WUR Discovery agent N.A. Investigative [18]
2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one DMSDYZQ Discovery agent N.A. Investigative [18]
2-hydroxyphenethyl 3,4,5-trihydroxybenzoate DMHK2NQ Discovery agent N.A. Investigative [19]
3,4-dihydroxybenzaldehyde-O-ethyloxime DMZJ4VL Discovery agent N.A. Investigative [20]
3-(2,4-dihydroxyphenyl)propionic acid DMXQROU Discovery agent N.A. Investigative [21]
3-hydroxyphenethyl 3,4,5-trihydroxybenzoate DMMAK83 Discovery agent N.A. Investigative [19]
3hydroxy-1-methyl-1-phenylurea DM4758S Discovery agent N.A. Investigative [13]
4',4-Dihydroxychalcone DMFPO16 Discovery agent N.A. Investigative [22]
4'-(4-Aminobenzensulfonamide)-4-hydroxychalcone DMGOTYC Discovery agent N.A. Investigative [22]
4'-(4-Fluorobenzensulfonamide)-4-hydroxychalcone DMA6E28 Discovery agent N.A. Investigative [22]
4'-(4-Nitrobenzensulfonamide)-4-hydroxychalcone DMHB1N6 Discovery agent N.A. Investigative [22]
4'-(Benzensulfonamide)-4-hydroxychalcone DML2EF4 Discovery agent N.A. Investigative [22]
4'-(p-Toluenesulfonamide)-4-hydroxychalcone DMRFWE1 Discovery agent N.A. Investigative [22]
4'-Amino-4-hydroxychalcone DM9S5V0 Discovery agent N.A. Investigative [22]
4,4'-(ethane-1,2-diyl)dibenzene-1,3-diol DM1NVEI Discovery agent N.A. Investigative [23]
4-(6-hydroxynaphthalen-2-yl)benzene-1,3-diol DM4SPV7 Discovery agent N.A. Investigative [24]
4-adamantyl resorcinol DME24LV Discovery agent N.A. Investigative [25]
4-hexyl resorcinol DM36JUD Discovery agent N.A. Investigative [26]
4-hydroxyphenethyl 3,4,5-trihydroxybenzoate DMJ7G0E Discovery agent N.A. Investigative [19]
5,5'-methylenebis(1,3,4-oxadiazole-2(3H)-thione) DMPVBC2 Discovery agent N.A. Investigative [15]
5,5'-methylenebis(1,3,4-thiadiazole-2(3H)-thione) DMW13SO Discovery agent N.A. Investigative [15]
5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione DM2H9ND Discovery agent N.A. Investigative [15]
5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione DMB2GLE Discovery agent N.A. Investigative [15]
5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol DMIB9AX Discovery agent N.A. Investigative [27]
5-(6-hydroxynaphthalen-2-yl)benzene-1,3-diol DMJRBKO Discovery agent N.A. Investigative [24]
5-(pyridin-4-yl)-1,3,4-oxadiazole-2(3H)-thione DM93MAX Discovery agent N.A. Investigative [15]
5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3H)-thione DMEL8XU Discovery agent N.A. Investigative [15]
5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione DM65WZ7 Discovery agent N.A. Investigative [15]
5-benzhydryl-1,3,4-thiadiazole-2(3H)-thione DMBQ5HV Discovery agent N.A. Investigative [15]
5-benzyl-1,3,4-oxadiazole-2(3H)-thione DM8QK2O Discovery agent N.A. Investigative [15]
5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione DMMYENH Discovery agent N.A. Investigative [15]
5-hydroxy-2-(pentylthiomethyl)-4H-pyran-4-one DMTO2L3 Discovery agent N.A. Investigative [17]
5-hydroxy-2-(propylthiomethyl)-4H-pyran-4-one DM7M1RZ Discovery agent N.A. Investigative [17]
5-phenyl-1,3,4-oxadiazole-2(3H)-thione DMZ6TRV Discovery agent N.A. Investigative [15]
5-phenyl-1,3,4-thiadiazole-2(3H)-thione DMCKBQY Discovery agent N.A. Investigative [15]
5-{8(Z),-pentadecenyl}resorcinol DMNRWEV Discovery agent N.A. Investigative [28]
5-{8(Z),11(Z),14-pentadecatrienyl}resorcinol DMSZ3T6 Discovery agent N.A. Investigative [28]
5-{8(Z),11(Z)-pentadecadienyl}resorcinol DM0EBWR Discovery agent N.A. Investigative [28]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol DMH8WA2 Discovery agent N.A. Investigative [24]
7,3',4'-trihydroxyisoflavone DM5JV8G Discovery agent N.A. Investigative [29]
7,8,4'-trihydroxyisoflavone DM80GFL Discovery agent N.A. Investigative [29]
7-(3,5-dihydroxyphenyl)naphthalene-1,3-diol DM9BS5L Discovery agent N.A. Investigative [24]
ASKENDOSIDE B DMTBZUC Discovery agent N.A. Investigative [30]
Broussonin C DMKM9F0 Discovery agent N.A. Investigative [31]
Crocusatin-K DMELUG5 Discovery agent N.A. Investigative [32]
DAEDALIN A DMWR3XL Discovery agent N.A. Investigative [9]
ETHISTERONE DMDXRP1 Discovery agent N.A. Investigative [33]
HINOKITIOL DMHL9Y6 Discovery agent N.A. Investigative [18]
Kazinol C DMS527J Discovery agent N.A. Investigative [31]
Kazinol F DMFVT81 Discovery agent N.A. Investigative [31]
KAZINOL S DMEV2AL Discovery agent N.A. Investigative [31]
KOJIC ACID DMP84CS Discovery agent N.A. Investigative [34]
Kojic acid-phenylalanine amide DMRB1AT Discovery agent N.A. Investigative [35]
N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamide DMNT3JV Discovery agent N.A. Investigative [36]
N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamide DM3IMXF Discovery agent N.A. Investigative [36]
N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamide DM6U8SL Discovery agent N.A. Investigative [36]
N-butylresorcinol DM8STQA Discovery agent N.A. Investigative [25]
OXYRESVERATROL DMN7S4L Discovery agent N.A. Investigative [16]
PHENYLTHIOUREA DMM1IAU Discovery agent N.A. Investigative [13]
ROSMARINIC ACID DMQ6SJT Rheumatoid arthritis FA20 Investigative [34]
S-2-(o-toluidino)-2-oxoethyl carbamothioate DMU9F7K Discovery agent N.A. Investigative [37]
SODIUM ZINC DIHYDROLIPOYLHISTIDINATE DMEZAPR Discovery agent N.A. Investigative [38]
SRI-224 DM35NF6 Discovery agent N.A. Investigative [20]
TROPOLONE DMOMXP7 Discovery agent N.A. Investigative [20]
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⏷ Show the Full List of 102 Investigative Drug(s)

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Melanoma 2C82 Skin 6.68E-04 2.54 1.15
Vitiligo EA90 Skin 5.23E-04 -0.7 -1.43
Rheumatoid arthritis FA20 Synovial tissue 5.99E-01 -0.14 -0.76
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