Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1O3BY)

• Drug Name: Mecasermin Drug Info
• Synonyms: Increlex (TN)

Indication

Disease Entry	ICD 11	Status	REF
Growth failure	LD2F.1Y	Approved	[1] , [2]

• Therapeutic Class: Immunomodulatory Agents
• Cross-matching ID: TTD Drug ID: DM1O3BY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Insulin-like growth factor I receptor (IGF1R)	TTHRID2	IGF1R_HUMAN	Inhibitor	[3] , [4] , [5] , [6]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Insulin-like growth factor I receptor (IGF1R)	DTT	IGF1R	4.542	5.508	6.35	5.558

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Growth failure
• ICD Disease Classification: LD2F.1Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Insulin-like growth factor I receptor (IGF1R)	DTT	IGF1R	1.64E-01	0.25	0.64

References

• [1] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [2] 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006).
• [3] IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 2003 Aug;443(2):139-45.
• [4] One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Arthritis Rheum. 2003 May;48(5):1302-14.
• [5] Analysis of the human type I insulin-like growth factor receptor promoter region. Biochem Biophys Res Commun. 1991 Jun 28;177(3):1113-20.
• [6] Insulin-like growth factor I receptor gene structure. J Biol Chem. 1992 May 25;267(15):10759-63.