Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1RE9Q)

Drug Name
2,3,4,5-Tetrahydro-1H-benzo[c]azepine Drug Info
Synonyms
2,3,4,5-Tetrahydro-1H-benzo[c]azepine; 7216-22-0; 2,3,4,5-tetrahydro-1H-2-benzazepine; 1H-2-Benzazepine, 2,3,4,5-tetrahydro-; CHEMBL118310; SCHEMBL233066; ARK042; CTK2H2810; DTXSID00440260; SIQBPWRTJNBBER-UHFFFAOYSA-N; MolPort-020-016-004; BDBM50052883; ANW-49031; ZINC13516868; AKOS005264678; MCULE-2809792553; AB49623; 2,3,4,5-tetrahydro 1H-2-benzazepine; BS-13541; BR-76361; AJ-64016; TC-137776; DB-074526; W8089; ST24021451; FT-0707305; 4CH-000440; S-5095; 2,3,4,5-tetrahydro-1H-benzo[c]azepine, AldrichCPR
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10464472
CAS Number
CAS 7216-22-0
TTD Drug ID
DM1RE9Q

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-2A (ADRA2A) TTWG9A4 ADA2A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2B (ADRA2B) TTWM4TY ADA2B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 5.013 2.379 5.594 2.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46.