Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1WMOK)

Drug Name
Generx Drug Info
Synonyms Alferminogene tadenovec
Indication
Disease Entry ICD 11 Status REF
Angina pectoris BA40 Phase 3 [1]
Cross-matching ID
TTD Drug ID
DM1WMOK

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fibroblast growth factor-4 (FGF4) TTCEKVZ FGF4_HUMAN Replacement [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Fibroblast growth factor-4 (FGF4) DTT FGF4 7.239 6.847 6.564 7.131
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Angina pectoris
ICD Disease Classification BA40
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Fibroblast growth factor-4 (FGF4) DTT FGF4 1.74E-01 0.04 0.45
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01550614) Efficacy and Safety of Ad5FGF-4 for Myocardial Ischemia in Patients With Stable Angina Due to Coronary Artery Disease (ASPIRE). U.S. National Institutes of Health.
2 Effects of Ad5FGF-4 in patients with angina: an analysis of pooled data from the AGENT-3 and AGENT-4 trials. J Am Coll Cardiol. 2007 Sep 11;50(11):1038-46.