Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM235CQ)

Drug Name

1-Hydroxy-10H-anthracen-9-one Drug Info

Synonyms

1-Hydroxyanthrone; 1-Hydroxy-9-anthrone; 1715-81-7; 1-Hydroxy-10H-anthracen-9-one; 9-Anthrone, 1-hydroxy-; 9-Anthronol; BRN 3530761; CHEMBL123161; 1-HYDROXY-9,10-DIHYDROANTHRACEN-9-ONE; hydroxyanthrone; AC1L45BO; SCHEMBL1204733; CTK4D3980; DTXSID10169112; 1-Hydroxyanthracen-9(10H)-one; MolPort-022-384-226; 9(10H)-Anthracenone,1-hydroxy-; ZINC6117388; BDBM50060879; AKOS022650101; LS-20754

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 150937
CAS Number: CAS 1715-81-7
TTD Drug ID: DM235CQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80.