Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM24E08)

• Drug Name: (2-Indol-1-yl-ethyl)-dimethyl-amine Drug Info
• Synonyms: 1H-Indole-1-ethanamine, N,N-dimethyl-; CHEMBL38633; 87482-09-5; (2-Indol-1-yl-ethyl)-dimethyl-amine; SCHEMBL4060777; CTK3C3615; DTXSID80579188; PSHKCPACSIZILK-UHFFFAOYSA-N; (2-Indol-1-ylethyl)dimethylamine; BDBM50108308; N,N-Dimethyl-1H-indole-1-ethanamine; AKOS013123773; [2-(1H-indol-1-yl)ethyl]dimethylamine; 2-(1H-Indol-1-yl)-N,N-dimethylethan-1-amine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 15893127
  CAS Number: CAS 87482-09-5
  TTD Drug ID: DM24E08

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2A receptor (HTR2A)	DTT	HTR2A	1.68E-01	-0.3	-0.14
5-HT 2A receptor (HTR2A)	DTT	HTR2A	5.59E-01	0.15	0.21

References

• [1] Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8.