Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2A75P)

Drug Name	PMID28454500-Compound-96 Drug Info
Cross-matching ID	PubChem CID 2761171 ChEBI ID CHEBI:4885 CAS Number CAS 536-33-4 TTD Drug ID DM2A75P ACDINA Drug ID D00253

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nuclear factor erythroid 2-related factor 2 (Nrf2)	TTA6ZN2	NF2L2_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nuclear factor erythroid 2-related factor 2 (Nrf2)	DTT	NFE2L2	8.964	8.362	9.046	8.808

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nuclear factor erythroid 2-related factor 2 (Nrf2)	DTT	NFE2L2	4.75E-12	-0.28	-0.58

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785.