Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2M47Y)

Drug Name
TKM-ApoB Drug Info
Indication
Disease Entry ICD 11 Status REF
Hypercholesterolaemia 5C80.0 Phase 4 [1]
Cross-matching ID
TTD Drug ID
DM2M47Y

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
APOB messenger RNA (APOB mRNA) TTN1IE2 APOB_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
APOB messenger RNA (APOB mRNA) DTT APOB 12.307 5.638 5.792 11.706
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Hypercholesterolaemia
ICD Disease Classification 5C80.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
APOB messenger RNA (APOB mRNA) DTT APOB 9.53E-01 0.03 0.18
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00348686) Candesartan Effectiveness Study in Pro-B Type Natriuretic Peptides (BNP). U.S. National Institutes of Health.
2 Current Progress of siRNA/shRNA Therapeutics in Clinical Trials. Biotechnol J. 2011 September; 6(9): 1130-1146.