Details of the Drug

General Information of Drug (ID: DM2M47Y)

Drug Name
TKM-ApoB
Indication
Disease Entry ICD 11 Status REF
Hypercholesterolaemia 5C80.0 Phase 4 [1]
Drug Type
siRNA drug
Cross-matching ID
TTD ID
D04VOZ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
APOB messenger RNA (APOB mRNA) TTN1IE2 APOB_HUMAN Not Available [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Hypercholesterolaemia
ICD Disease Classification 5C80.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
APOB messenger RNA (APOB mRNA) DTT APOB 9.53E-01 0.03 0.18
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT00348686) Candesartan Effectiveness Study in Pro-B Type Natriuretic Peptides (BNP). U.S. National Institutes of Health.
2 Current Progress of siRNA/shRNA Therapeutics in Clinical Trials. Biotechnol J. 2011 September; 6(9): 1130-1146.