Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2THVK)

Drug Name

1-(4-Cyanobenzyl)-5-formyl-1H-imidazole Drug Info

Synonyms

183500-37-0; CHEMBL611680; 4-(5-formylimidazol-1-ylmethyl)benzonitrile; 4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile; 4-(5-FORMYL-IMIDAZOL-1-YLMETHYL)-BENZONITRILE; 4-((5-formyl-1h-imidazol-1-yl)methyl)benzonitrile; 1-(4-Cyanobenzyl)-5-formyl-1H-imidazole; SCHEMBL1064258; CTK4D8501; DTXSID30442752; AMUOEEKBBOOOCV-UHFFFAOYSA-N; ZINC39118604; BDBM50307239; 1-(4-cyanobenzyl)-5-formylimidazole; AKOS015911901; ACM183500370; SC-55448; KB-238611; FT-0714561; 1-(4-cyanobenzyl)-5-imidazolecarboxaldehyde

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10632289
CAS Number: CAS 183500-37-0
TTD Drug ID: DM2THVK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25.