Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTIQUX7)

• DTT Name: Steroid 11-beta-hydroxylase (CYP11B1)
• Synonyms: S11BH; P450C11; P-450c11; CYPXIB1; CYP11B1
• Gene Name: CYP11B1
• DTT Type: Successful target; [1]
• BioChemical Class: Paired donor oxygen oxidoreductase
• UniProt ID: C11B1_HUMAN
• TTD ID: T84621
• EC Number: EC 1.14.15.4
• Sequence:
  MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
  YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
  QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
  RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
  PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
  PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
  ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
  ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
  IKMVYSFILRPSMFPLLTFRAIN
• Function: Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
• KEGG Pathway:
  Steroid hormone biosynthesis (hsa00140)
  Metabolic pathways (hsa01100)
• Reactome Pathway:
  Endogenous sterols (R-HSA-211976)
  Glucocorticoid biosynthesis (R-HSA-194002)
• BioCyc Pathway: MetaCyc:HS08547-MON

Molecular Interaction Atlas (MIA) of This DTT

3 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[2]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[1]
Osilodrostat	DMIJC9X	Cushing disease	5A70	Approved	[3]

148 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(3-((1H-imidazol-1-yl)methyl)phenyl)methanol	DMBZJT5	Discovery agent	N.A.	Investigative	[2]
(4-((1H-imidazol-1-yl)methyl)phenyl)methanol	DMWS35F	Discovery agent	N.A.	Investigative	[2]
1-(2-Phenoxy-ethyl)-1H-imidazole	DMOMAXJ	Discovery agent	N.A.	Investigative	[4]
1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole	DMP93HZ	Discovery agent	N.A.	Investigative	[5]
1-(3-Bromobenzyl)-1H-imidazole	DMA59TP	Discovery agent	N.A.	Investigative	[2]
1-(3-Chlorobenzyl)-1H-imidazole	DM3SQBH	Discovery agent	N.A.	Investigative	[2]
1-(3-Fluorobenzyl)-1H-imidazole	DM18DB3	Discovery agent	N.A.	Investigative	[2]
1-(3-Methoxy-naphthalen-2-yl)-1H-imidazole	DM16U5F	Discovery agent	N.A.	Investigative	[6]
1-(4-Aminobenzyl)-1H-imidazole	DMOZAM6	Discovery agent	N.A.	Investigative	[2]
1-(4-Bromobenzyl)-1H-imidazole	DM2C7U0	Discovery agent	N.A.	Investigative	[2]
1-(4-Bromobenzyl)-5-phenyl-1H-imidazole	DMCW8RT	Discovery agent	N.A.	Investigative	[2]
1-(4-Chlorobenzyl)-5-phenyl-1H-imidazole	DMASLUF	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-(2-fluorophenyl)-1H-imidazole	DMKDAJ2	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-(2-methylphenyl)-1H-imidazole	DMAJXYO	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-(3-fluorophenyl)-1H-imidazole	DMVS4D5	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-(3-methylphenyl)-1H-imidazole	DMI8UC7	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-(4-fluorophenyl)-1H-imidazole	DM7C3VD	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-(4-methylphenyl)-1H-imidazole	DMQX37R	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-(4-pyridyl)-1H-imidazole	DM372EG	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-bromo-1H-imidazole	DMBUMDG	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-formyl-1H-imidazole	DM2THVK	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-hydroxymethyl-1H-imidazole	DMCUE25	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-methyl-1H-imidazole	DMKC52N	Discovery agent	N.A.	Investigative	[2]
1-(4-Cyanobenzyl)-5-phenyl-1H-imidazole	DMQF8DY	Discovery agent	N.A.	Investigative	[2]
1-(4-fluorobenzyl)-1H-imidazole	DMBJCGA	Discovery agent	N.A.	Investigative	[2]
1-(4-Fluorobenzyl)-5-phenyl-1H-imidazole	DMT2ZSV	Discovery agent	N.A.	Investigative	[2]
1-(4-Methoxybenzyl)-5-phenyl-1H-imidazole	DMSWJKZ	Discovery agent	N.A.	Investigative	[2]
1-(6-Methoxy-naphthalen-2-yl)-1H-imidazole	DMEHK4F	Discovery agent	N.A.	Investigative	[6]
1-Benzyl-5-phenyl-1H-imidazole	DM8GUN9	Discovery agent	N.A.	Investigative	[2]
1-Ethyl-3-imidazol-1-ylmethyl-1H-indole	DM5UWH9	Discovery agent	N.A.	Investigative	[7]
1-Naphthalen-2-yl-1H-imidazole	DMTBZJL	Discovery agent	N.A.	Investigative	[6]
1-Phenyl-2-pyridin-3-yl-propan-1-one	DM8EDI7	Discovery agent	N.A.	Investigative	[8]
2-Methyl-1,2-di-pyridin-3-yl-1-methoxypropane	DMIWX21	Discovery agent	N.A.	Investigative	[8]
2-Methyl-1,2-di-pyridin-3-yl-propan-1-one oxime	DMB0NEL	Discovery agent	N.A.	Investigative	[8]
2-Methyl-1,2-di-pyridin-3-yl-propane	DMC3ET2	Discovery agent	N.A.	Investigative	[8]
2-Methyl-1,2-di-pyridin-3-yl-propylchloride	DMQHM7R	Discovery agent	N.A.	Investigative	[8]
2-Methyl-1,2-di-pyridin-3-yl-propyliodide	DM561MH	Discovery agent	N.A.	Investigative	[8]
2-Methyl-1-phenyl-2-pyridin-3-yl-propan-1-ol	DMLX9RG	Discovery agent	N.A.	Investigative	[8]
2-Methyl-1-phenyl-2-pyridin-3-yl-propan-1-one	DMZY72I	Discovery agent	N.A.	Investigative	[8]
3-((1H-imidazol-1-yl)methyl)aniline	DMZ9L6Q	Discovery agent	N.A.	Investigative	[2]
3-(1,1-Dimethyl-2-phenyl-ethyl)-pyridine	DM57ZMJ	Discovery agent	N.A.	Investigative	[8]
3-(1,2-dihydroacenaphthylen-3-yl)pyridine	DMXZBQL	Discovery agent	N.A.	Investigative	[9]
3-(1,2-dihydroacenaphthylen-5-yl)pyridine	DMHB4PA	Discovery agent	N.A.	Investigative	[9]
3-(1-Benzyl-1H-imidazol-5-yl)-1-propanol	DMGYDEK	Discovery agent	N.A.	Investigative	[2]
3-(1-Chloro-7-methoxy-naphthalen-2-yl)-pyridine	DMLH7YI	Discovery agent	N.A.	Investigative	[6]
3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine	DMR7M82	Discovery agent	N.A.	Investigative	[5]
3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine	DMU5HMC	Discovery agent	N.A.	Investigative	[5]
3-(1H-inden-2-yl)pyridine	DM9ZDIK	Discovery agent	N.A.	Investigative	[5]
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)pyridine	DMTS4YD	Discovery agent	N.A.	Investigative	[10]
3-(2-Chloro-1,1-dimethyl-2-phenyl-ethyl)-pyridine	DMDS4Q0	Discovery agent	N.A.	Investigative	[8]
3-(3,4-dihydronaphthalen-2-yl)pyridine	DM0VL17	Discovery agent	N.A.	Investigative	[5]
3-(3-Benzyl-6-methoxynaphthalen-2-yl)pyridine	DM1325C	Discovery agent	N.A.	Investigative	[11]
3-(3-Benzylnaphthalen-2-yl)pyridine	DM9S36A	Discovery agent	N.A.	Investigative	[11]
3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine	DM2YLBD	Discovery agent	N.A.	Investigative	[5]
3-(4-ethyl-3,4-dihydronaphthalen-2-yl)pyridine	DMM7BQP	Discovery agent	N.A.	Investigative	[5]
3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine	DMDR20P	Discovery agent	N.A.	Investigative	[5]
3-(5,6,7,8-Tetrahydronaphthalen-2-yl)pyridine	DMTVYLM	Discovery agent	N.A.	Investigative	[10]
3-(5-Bromo-6-methoxy-naphthalen-2-yl)-pyridine	DMUIXNS	Discovery agent	N.A.	Investigative	[6]
3-(5-Chloro-6-methoxy-naphthalen-2-yl)-pyridine	DM67DVU	Discovery agent	N.A.	Investigative	[6]
3-(5-methoxy-1H-inden-2-yl)pyridine	DMTJXOU	Discovery agent	N.A.	Investigative	[5]
3-(6-Bromo-naphthalen-2-yl)-pyridine	DM63BI9	Discovery agent	N.A.	Investigative	[6]
3-(6-Ethoxy-naphthalen-2-yl)-pyridine	DMUQ0WI	Discovery agent	N.A.	Investigative	[6]
3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine	DMAJHXO	Discovery agent	N.A.	Investigative	[12]
3-(6-Methoxy-3-methylnaphthalen-2-yl)pyridine	DMISLV4	Discovery agent	N.A.	Investigative	[12]
3-(6-Methoxynaphthalen-2-yl)-4-methylpyridine	DM0GXFB	Discovery agent	N.A.	Investigative	[12]
3-(6-Methoxynaphthalen-2-yl)-5-phenylpyridine	DM704R5	Discovery agent	N.A.	Investigative	[12]
3-(6-Methoxynaphthalen-2-yl)pyridin-4-amine	DMN75RD	Discovery agent	N.A.	Investigative	[12]
3-(6-methoxynaphthalen-2-yl)pyridine	DMYRJAB	Discovery agent	N.A.	Investigative	[11]
3-(naphthalen-2-yl)pyridine	DMJRBT1	Discovery agent	N.A.	Investigative	[11]
3-Ethoxy-5-(6-methoxynaphthalen-2-yl)pyridine	DMWZDA1	Discovery agent	N.A.	Investigative	[12]
3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol	DMJ3WNP	Discovery agent	N.A.	Investigative	[13]
3-Imidazol-1-yl-quinoline	DMVF6OQ	Discovery agent	N.A.	Investigative	[6]
3-Imidazol-1-ylmethyl-1H-indole	DMBZ60O	Discovery agent	N.A.	Investigative	[7]
3-Imidazol-1-ylmethyl-2-isopropyl-1H-indole	DMAQOL0	Discovery agent	N.A.	Investigative	[7]
3-Indan-(1E)-ylidenemethyl-pyridine	DMYH6A2	Discovery agent	N.A.	Investigative	[14]
3-Indan-(1Z)-ylidenemethyl-pyridine	DMTQERW	Discovery agent	N.A.	Investigative	[14]
3-MeSO2-DDE	DMAWEQH	Discovery agent	N.A.	Investigative	[1]
3-methoxy-5-(6-methoxynaphthalen-2-yl)pyridine	DMF2IW8	Discovery agent	N.A.	Investigative	[12]
3-Phenanthren-9-yl-pyridine	DM7RWQT	Discovery agent	N.A.	Investigative	[6]
3-[(Z)-2-phenylvinyl]pyridine	DMNPKZ6	Discovery agent	N.A.	Investigative	[5]
3-[1-(4-Bromobenzyl)-1H-imidazol-5-yl]-1-propanol	DM7URMW	Discovery agent	N.A.	Investigative	[2]
3-[1-(4-Cyanobenzyl)-1H-imidazol-5-yl]-1-propanol	DM63IKF	Discovery agent	N.A.	Investigative	[2]
3-[3-(4-Methoxybenzyl)naphthalen-2-yl]pyridine	DM8NRJQ	Discovery agent	N.A.	Investigative	[11]
3-[4-Chloro-indan-(1E)-ylidenemethyl]-pyridine	DM0XD6T	Discovery agent	N.A.	Investigative	[14]
3-[4-Chloro-indan-(1Z)-ylidenemethyl]-pyridine	DMMDIB9	Discovery agent	N.A.	Investigative	[14]
3-[4-Fluoro-indan-(1E)-ylidenemethyl]-pyridine	DMZS20Y	Discovery agent	N.A.	Investigative	[14]
3-[4-Methyl-indan-(1E)-ylidenemethyl]-pyridine	DMJN93U	Discovery agent	N.A.	Investigative	[14]
3-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine	DMUEVAQ	Discovery agent	N.A.	Investigative	[14]
3-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine	DMCXSIH	Discovery agent	N.A.	Investigative	[14]
3-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine	DM8TWLO	Discovery agent	N.A.	Investigative	[14]
3-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine	DMN60YG	Discovery agent	N.A.	Investigative	[14]
3-[5-Ethoxy-indan-(1E)-ylidenemethyl]-pyridine	DMLJQZS	Discovery agent	N.A.	Investigative	[14]
3-[5-Ethoxy-indan-(1Z)-ylidenemethyl]-pyridine	DMMTUON	Discovery agent	N.A.	Investigative	[14]
3-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine	DMWSFIR	Discovery agent	N.A.	Investigative	[14]
3-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine	DMN42I5	Discovery agent	N.A.	Investigative	[14]
3-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine	DM9AW5U	Discovery agent	N.A.	Investigative	[14]
3-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine	DMB3XYE	Discovery agent	N.A.	Investigative	[14]
3-[7-Methoxy-indan-(1E)-ylidenemethyl]-pyridine	DMVWIQ2	Discovery agent	N.A.	Investigative	[14]
4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diamine	DMZ0H5X	Discovery agent	N.A.	Investigative	[13]
4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol	DM6Z5EK	Discovery agent	N.A.	Investigative	[13]
4'-(Pyridin-4-ylmethyl)biphenyl-3-amine	DMR8O1B	Discovery agent	N.A.	Investigative	[13]
4'-(Pyridin-4-ylmethyl)biphenyl-4-amine	DM8HXYS	Discovery agent	N.A.	Investigative	[13]
4-((1H-imidazol-1-yl)methyl)benzonitrile	DMFUBRC	Discovery agent	N.A.	Investigative	[2]
4-((3',4'-Difluorobiphenyl-4-yl)methyl)pyridine	DMHN5OL	Discovery agent	N.A.	Investigative	[13]
4-(2-Imidazol-1-yl-ethoxy)-benzamide	DMB6SNE	Discovery agent	N.A.	Investigative	[4]
4-(4'-Fluoro-biphenyl-4-ylmethyl)pyridine	DM52NMU	Discovery agent	N.A.	Investigative	[13]
4-(4-(thiophen-2-yl)benzyl)pyridine	DMVXJU6	Discovery agent	N.A.	Investigative	[13]
4-(4-(thiophen-3-yl)benzyl)pyridine	DM7I21V	Discovery agent	N.A.	Investigative	[13]
4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine	DM3ACVD	Discovery agent	N.A.	Investigative	[5]
4-(6-Methoxy-3-methylnaphthalen-2-yl)isoquinoline	DMRPU0V	Discovery agent	N.A.	Investigative	[12]
4-(6-Methoxynaphthalen-2-yl)isoquinoline	DM51XDA	Discovery agent	N.A.	Investigative	[12]
4-Indan-(1Z)-ylidenemethyl-pyridine	DM25DR7	Discovery agent	N.A.	Investigative	[14]
4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine	DM04MK7	Discovery agent	N.A.	Investigative	[13]
4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine	DMIEMWA	Discovery agent	N.A.	Investigative	[13]
4-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine	DMI7YAQ	Discovery agent	N.A.	Investigative	[14]
4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine	DMQKHXN	Discovery agent	N.A.	Investigative	[14]
4-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine	DMZL8KN	Discovery agent	N.A.	Investigative	[14]
4-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine	DM1Z3DG	Discovery agent	N.A.	Investigative	[14]
4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine	DMY08FE	Discovery agent	N.A.	Investigative	[14]
4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine	DMHDZUO	Discovery agent	N.A.	Investigative	[14]
5-(6-Methoxynaphthalen-2-yl)pyridin-3-ol	DMMPAWD	Discovery agent	N.A.	Investigative	[12]
5-Indan-(1E)-ylidenemethyl-1H-imidazole	DMW8AOM	Discovery agent	N.A.	Investigative	[15]
5-Indan-(1Z)-ylidenemethyl-1H-imidazole	DMKLY20	Discovery agent	N.A.	Investigative	[15]
5-Naphthalen-2-yl-1H-imidazole	DMK0PAL	Discovery agent	N.A.	Investigative	[6]
5-Naphthalen-2-yl-oxazole	DMTH3BW	Discovery agent	N.A.	Investigative	[6]
5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one	DMLRM9Z	Discovery agent	N.A.	Investigative	[10]
5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one	DMQYIBC	Discovery agent	N.A.	Investigative	[10]
5-[4-(Pyridin-4-ylmethyl)phenyl]-1H-indole	DMW8RLN	Discovery agent	N.A.	Investigative	[13]
5-[5-Bromo-indan-(1E)-ylidenemethyl]-1H-imidazole	DMV7QU3	Discovery agent	N.A.	Investigative	[15]
5-[5-Bromo-indan-(1Z)-ylidenemethyl]-1H-imidazole	DMZICL8	Discovery agent	N.A.	Investigative	[15]
5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine	DM2RIHT	Discovery agent	N.A.	Investigative	[14]
6-(4-Methylpyridin-3-yl)-2-naphthonitrile	DMTV753	Discovery agent	N.A.	Investigative	[12]
6-(pyridin-3-yl)-2-naphthonitrile	DMC3SJI	Discovery agent	N.A.	Investigative	[12]
6-Isoquinolin-4-yl-3,4-dihydroquinolin-2(1H)-one	DM2WUZP	Discovery agent	N.A.	Investigative	[10]
6-Pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-2-ol	DM86XG5	Discovery agent	N.A.	Investigative	[10]
6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one	DMG5ABT	Discovery agent	N.A.	Investigative	[10]
6-Pyridin-3-yl-3,4-dihydronaphthalen-2(1H)-one	DMIM5DL	Discovery agent	N.A.	Investigative	[10]
6-Pyridin-3-yl-3,4-dihydroquinoline-2(1H)-thione	DMHAS2B	Discovery agent	N.A.	Investigative	[10]
6-Pyridin-3-yl-naphthalen-2-ol	DMGWNDB	Discovery agent	N.A.	Investigative	[6]
6-[4-(Pyridin-4-ylmethyl)phenyl]naphthalen-2-ol	DM40LQ9	Discovery agent	N.A.	Investigative	[13]
7-(1-(1H-imidazol-1-yl)ethyl)-9H-fluoren-2-ol	DMRPFNU	Discovery agent	N.A.	Investigative	[16]
7-Pyridin-3-yl-2H-1,4-benzothiazin-3(4H)-one	DMW8XME	Discovery agent	N.A.	Investigative	[10]
BENZYLIMIDAZOLE	DMNRHSO	Discovery agent	N.A.	Investigative	[2]
Methyl 3-(1-Benzyl-1H-imidazol-5-yl)-propanoate	DMWM814	Discovery agent	N.A.	Investigative	[2]
METYRAPOL	DMHTGCR	Discovery agent	N.A.	Investigative	[8]
N-(4'-Isonicotinoylbiphenyl-3-yl)acetamide	DM2N3TG	Discovery agent	N.A.	Investigative	[13]
R-fadrozole	DMJG4U0	Discovery agent	N.A.	Investigative	[2]
SL125	DMEIZ20	Congestive heart failure	BD10	Investigative	[17]

Molecular Expression Atlas (MEA) of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Breast cancer	2C82	Breast tissue	4.31E-04	-0.03	-0.13
Prostate cancer	2C82	Prostate	2.68E-02	-0.35	-0.77

The Drug-Metabolizing Enzyme (DME) Role of This DTT

• DTT DME Name: Steroid 11-beta-hydroxylase (CYP11B1) DME Info
• Gene Name: CYP11B1

2 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[18]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[19]

1 Investigative Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
deoxycorticosterone	DMW6YLS	Discovery agent	N.A.	Investigative	[20]

References

• [1] Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. Toxicol In Vitro. 2002 Apr;16(2):113-21.
• [2] Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [4] Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles. J Med Chem. 1985 Oct;28(10):1427-32.
• [5] Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31.
• [6] Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42.
• [7] Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. J Med Chem. 1986 Mar;29(3):342-6.
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