Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2U16Z)

Drug Name

ANAVEX 1007 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Preclinical	[1]
Pancreatic cancer	2C10	Preclinical	[1]
Prostate cancer	2C82.0	Preclinical	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor sigma 1 (OPRS1)	TT5TPI6	SGMR1_HUMAN	Agonist	[1]
Sigma intracellular receptor 2 (TMEM97)	TT9NXW4	SGMR2_HUMAN	Agonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Opioid receptor sigma 1 (OPRS1)	DTT	SIGMAR1	7.092	5.716	5.411	6.434

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Melanoma

ICD Disease Classification

2C30

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Opioid receptor sigma 1 (OPRS1)	DTT	SIGMAR1	2.77E-06	-0.12	-0.62

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	2011 Pipeline of Anavex.