Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM35LJC)

Drug Name
Anpirtoline Drug Info
Synonyms D-16949
Indication
Disease Entry ICD 11 Status REF
Pain MG30-MG3Z Terminated [1]
Cross-matching ID
PubChem CID
65854
ChEBI ID
CHEBI:92968
CAS Number
CAS 98330-05-3
TTD Drug ID
DM35LJC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Modulator [1]
5-HT 1B receptor (HTR1B) TTK8CXU 5HT1B_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 1A receptor (HTR1A) DTT HTR1A 4.661 5.289 3.053 3.472
5-HT 1B receptor (HTR1B) DTT HTR1B 5.781 3.121 6.267 4.986
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Pain
ICD Disease Classification MG30-MG3Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 1A receptor (HTR1A) DTT HTR1A 2.18E-01 -0.11 -0.51
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study. Nucl Med Biol. 2006 Apr;33(3):325-32.