Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM35NF6)

Drug Name

SRI-224 Drug Info

Synonyms

SRI-224; CHEMBL223505; [(E)-1-(4-methoxyphenyl)ethylideneamino]thiourea; p-Methoxyacetophenone thiosemicarbazone; 1-(4-methoxyphenyl)ethanone thiosemicarbazone; MolPort-000-248-698; ZINC15224175; BDBM50302754; AKOS000506378; p-methoxyphenyl(methyl)thiosemicarbazone; KB-89903; ST085316; BAS 00232870; 9P-047; SR-01000310617; [(E)-[1-(4-methoxyphenyl)ethylidene]amino]thiourea; SR-01000310617-1; (1E)-1-(4-methoxyphenyl)ethanone thiosemicarbazone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9561005
TTD Drug ID: DM35NF6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosinase (TYR)	DTT	TYR	5.959	5.711	5.973	4.912

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	6.68E-04	2.54	1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6157-60.