Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3FXPS)

Drug Name

Liraglutide Drug Info

Synonyms

Liraglutida; Liraglutidum; Victoza; NN 2211; NN2211; Liraglutida [INN-Spanish]; Liraglutide [USAN:INN]; Liraglutidum [INN-Latin]; NN-2211; Victoza (TN); N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)GLP-1-(7-37)-peptide; N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide

Indication

Disease Entry	ICD 11	Status	REF
Non-insulin dependent diabetes	5A11	Approved	[1]
Type-2 diabetes	5A11	Approved	[2]
Obesity	5B81	Phase 2	[2]

Cross-matching ID

PubChem CID: 16134956
ChEBI ID: CHEBI:71193
CAS Number: CAS 204656-20-2
TTD Drug ID: DM3FXPS
INTEDE Drug ID: DR0962

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon-like peptide 1 receptor (GLP1R)	TTVIMDE	GLP1R_HUMAN	Agonist	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Neprilysin (MME)	DEVN830	NEP_HUMAN	Approved	[4]
Dipeptidyl peptidase IV (DPP4)	DEKZQY6	DPP4_HUMAN	Approved	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glucagon-like peptide 1 receptor (GLP1R)	DTT	GLP1R	2	2.848	3.472	2.963
Neprilysin (MME)	DME	MME	4.902	3.07	6.988	9.452
Dipeptidyl peptidase IV (DPP4)	DME	DPP4	4.995	4.926	7.852	8.358

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Non-insulin dependent diabetes

ICD Disease Classification

5A11

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glucagon-like peptide 1 receptor (GLP1R)	DTT	GLP1R	1.25E-01	0.17	1.26
Neprilysin (MME)	DME	MME	3.54E-01	4.98E-01	9.92E-01
Dipeptidyl peptidase IV (DPP4)	DME	DPP4	9.54E-01	-2.74E-01	-1.85E+00

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Liraglutide FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1133).
3	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
4	Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Dispos. 2010 Nov;38(11):1944-53.