Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3Q1SM)

Drug Name
obeticholic acid Drug Info
Synonyms INT747; INT-747; 6-ethylchenodeoxycholic acid; 6-ECDCA; OCA; 6-Et CDCA
Indication
Disease Entry ICD 11 Status REF
Primary biliary cholangitis DB96.1 Approved [1]
Insomnia 7A00-7A0Z Clinical trial [2]
Cross-matching ID
PubChem CID
447715
ChEBI ID
CHEBI:43602
CAS Number
CAS 459789-99-2
TTD Drug ID
DM3Q1SM
INTEDE Drug ID
DR1183
ACDINA Drug ID
D00482

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Farnesoid X-activated receptor (FXR) TTS4UGC NR1H4_HUMAN Modulator [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Bile acid-CoA thioesterase (BAAT) DERA3OF BAAT_HUMAN Approved [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Farnesoid X-activated receptor (FXR) DTT NR1H4 9.173 5.722 7.333 6.967
Bile acid-CoA thioesterase (BAAT) DME BAAT 8.568 1.585 2.433 1.632
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Primary biliary cholangitis
ICD Disease Classification DB96.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Farnesoid X-activated receptor (FXR) DTT NR1H4 5.72E-01 0.39 1.68
Bile acid-CoA thioesterase (BAAT) DME BAAT 9.73E-01 -6.99E-02 -2.12E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
2 Nuclear receptors and lipid physiology: opening the X-files. Science. 2001 Nov 30;294(5548):1866-70.
3 Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. J Biol Chem. 1994 Jul 29;269(30):19375-9.