Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3WBZP)

Drug Name

N-(1-benzofuran-3-ylmethyl)sulfamide Drug Info

Synonyms

CHEMBL1077117; N-(1-benzofuran-3-ylmethyl)sulfamide; Sulfamide, N-(3-benzofuranylmethyl)-; SCHEMBL4279478; XOBOZYKTCAJRGO-UHFFFAOYSA-N; N-(3-benzofuranylmethyl)-sulfamide; BDBM50310434

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11521450
TTD Drug ID: DM3WBZP

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into huma... J Med Chem. 2009 Dec 10;52(23):7528-36.