Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTANPDJ)

DTT Name Carbonic anhydrase II (CA-II)
Synonyms Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
Gene Name CA2
DTT Type
Successful target
 [1]
Related Disease
Bacterial infection [ICD-11: 1A00-1C4Z]
Essential hypertension [ICD-11: BA00]
Glaucoma [ICD-11: 9C61]
Heart failure [ICD-11: BD10-BD1Z]
Insomnia [ICD-11: 7A00-7A0Z]
Seborrhoeic dermatitis [ICD-11: EA81]
BioChemical Class
Alpha-carbonic anhydrase
UniProt ID
CAH2_HUMAN
TTD ID
T20401
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 4.2.1.1
Sequence
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
Function
Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation.
KEGG Pathway
Nitrogen metabolism (hsa00910 )
Proximal tubule bicarbonate reclamation (hsa04964 )
Collecting duct acid secretion (hsa04966 )
Gastric acid secretion (hsa04971 )
Pancreatic secretion (hsa04972 )
Bile secretion (hsa04976 )
Reactome Pathway
Erythrocytes take up oxygen and release carbon dioxide (R-HSA-1247673 )
Reversible hydration of carbon dioxide (R-HSA-1475029 )
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
9 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzthiazide DMQWZ0H High blood pressure BA00 Approved [1], [2]
Chlorothiazide DMLHESP Congestive heart failure BD10 Approved [3]
Cyclothiazide DMJ4AWC Congestive heart failure BD10 Approved [4]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [5]
Dorzolamide DMA17D0 Open-angle glaucoma 9C61 Approved [6]
Ethinamate DMK57GB Insomnia 7A00-7A0Z Approved [7]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [5]
Salicyclic acid DM2F8XZ Seborrhoeic dermatitis EA81 Approved [8]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [9]
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⏷ Show the Full List of 9 Approved Drug(s)
10 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [10]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [11]
Guaiacol DMN4E7T N. A. N. A. Phase 3 [12]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [13]
SULTHIAME DM07653 N. A. N. A. Phase 3 [5]
Phenol DM1QSM3 N. A. N. A. Phase 2/3 [11]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [14]
STX-140 DMJK5CT Osteoporosis FB83.0 Phase 2 [15]
BUTYLATEDHYDROXYTOLUENE DMJ56MS N. A. N. A. Phase 1 [12]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [16]
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⏷ Show the Full List of 10 Clinical Trial Drug(s)
1 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ferulic Acid DMJC7NF Discovery agent N.A. Patented [13]
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259 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
(2,2-dimethyl-1,3-dioxolan-4-yl)methyl sulfamate DM2ATRC Discovery agent N.A. Investigative [17]
(2-bromophenyl)difluoromethanesulfonamide DMFX9H8 Discovery agent N.A. Investigative [18]
(4-bromophenyl)difluoromethanesulfonamide DMOCYZJ Discovery agent N.A. Investigative [18]
1,2,4-Triazole DM73F5A Discovery agent N.A. Investigative [19]
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide DMNHGVD Discovery agent N.A. Investigative [20]
1,4-phenylene disulfamate DMEDBO2 Discovery agent N.A. Investigative [21]
1-(3,4-dichlorophenyl)-3-hydroxyurea DMVOJ7K Discovery agent N.A. Investigative [22]
1-acetamido-5-sulfonamidoindane DM92ZCU Discovery agent N.A. Investigative [23]
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide DMUXSH5 Discovery agent N.A. Investigative [20]
1-cyclohexylamido-5-sulfonamidoindane DMFPQME Discovery agent N.A. Investigative [23]
1-pentafluorophenylamido-5-sulfonamidoindane DM9PNTQ Discovery agent N.A. Investigative [23]
1-pentenyl-4-(aminosulfonyl)benzoate DMNUAB9 Discovery agent N.A. Investigative [24]
1-valproylamido-5-sulfonamidoindane DM9ZRU2 Discovery agent N.A. Investigative [23]
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide DMG4ITB Discovery agent N.A. Investigative [25]
2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide DMATB8H Discovery agent N.A. Investigative [25]
2,3-dihydro-1H-indene-5-sulfonamide DM46MKY Discovery agent N.A. Investigative [5], [26]
2,4-dichloro-5-sulfamoylbenzoic acid DM4EY5S Discovery agent N.A. Investigative [27]
2,4-Disulfamyltrifluoromethylaniline DM2AW0Z Discovery agent N.A. Investigative [28]
2,6-di-t-butylphenol DMY8LDT Discovery agent N.A. Investigative [12]
2,6-di-tert-butyl-4-methoxyphenol DMFO1H2 Discovery agent N.A. Investigative [12]
2,6-Difluorobenzenesulfonamide DMGEYAK Discovery agent N.A. Investigative [29]
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide DM1JKWL Discovery agent N.A. Investigative [30]
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide DMFGQ7K Discovery agent N.A. Investigative [30]
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide DMRADWB Discovery agent N.A. Investigative [30]
2-(4-hydroxybenzylideneamino)ethanesulfonamide DMCPN7V Discovery agent N.A. Investigative [31]
2-(4-tert-butylbenzylideneamino)ethanesulfonamide DMIOW3D Discovery agent N.A. Investigative [31]
2-(benzylideneamino)ethanesulfonamide DM3VJLZ Discovery agent N.A. Investigative [31]
2-(benzyloxyamino)-N-hydroxyhexanamide DMOUKTH Discovery agent N.A. Investigative [30]
2-(N''-Acetyl-hydrazino)-benzenesulfonamide DMHYKR8 Discovery agent N.A. Investigative [32]
2-acetamido-5-sulfonamidoindane DMPKBVR Discovery agent N.A. Investigative [23]
2-Acetylamino-indan-5-sulfonic acid hydrate DMEQKIU Discovery agent N.A. Investigative [26]
2-Amino-benzenesulfonamide DMEMANH Discovery agent N.A. Investigative [28]
2-Amino-indan-5-sulfonic acid DMCUSH1 Discovery agent N.A. Investigative [26]
2-butylamido-5-sulfonamidoindane DML9MCU Discovery agent N.A. Investigative [23]
2-cyclohexylamido-5-sulfonamidoindane DMFBD3K Discovery agent N.A. Investigative [23]
2-ethylamido-5-sulfonamidoindane DMDY3JQ Discovery agent N.A. Investigative [23]
2-Hydrazinocarbonyl-benzenesulfonamide DMG78U2 Discovery agent N.A. Investigative [32]
2-hydrazinylbenzenesulfonamide DMCNXZM Discovery agent N.A. Investigative [6]
2-Hydroxycinnamic acid DM86HTZ Discovery agent N.A. Investigative [11]
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide DMXEUDM Discovery agent N.A. Investigative [5], [33]
2-methoxyestradiol-17-O-sulfamate DMIBKNZ Discovery agent N.A. Investigative [15]
2-methoxyestrrone-3-O-sulfamate DMD6L7C Discovery agent N.A. Investigative [15]
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide DMDTRZ2 Discovery agent N.A. Investigative [34]
2-nonylamido-5-sulfonamidoindane DMOGWIK Discovery agent N.A. Investigative [23]
2-oxo-2H-thiochromene-3-carboxylic acid DMZTCOM Discovery agent N.A. Investigative [35]
2-pentafluorophenylamido-5-sulfonamidoindane DMZ9NCA Discovery agent N.A. Investigative [23]
2-propylamido-5-sulfonamidoindane DMG0I25 Discovery agent N.A. Investigative [23]
2-Sulfamoyl-benzoic acid methyl ester DMAO7DS Discovery agent N.A. Investigative [32]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [19]
2-valproylamido-5-sulfonamidoindane DM8XSE3 Discovery agent N.A. Investigative [23]
3,5-Difluorobenzenesulfonamide DMET46F Discovery agent N.A. Investigative [19]
3-((4-aminophenyl)diazenyl)benzenesulfonamide DM37X04 Discovery agent N.A. Investigative [36]
3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide DMAPZQW Discovery agent N.A. Investigative [36]
3-(3-Phenyl-ureido)-benzenesulfonamide DM314ZE Discovery agent N.A. Investigative [25]
3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide DM18MOH Discovery agent N.A. Investigative [36]
3-(4-sulfamoylphenyl)propanoic acid DMBDW8P Discovery agent N.A. Investigative [5], [28]
3-Amino-benzenesulfonamide DME0TNA Discovery agent N.A. Investigative [37]
3-bromophenyl-difluoromethanesulfonamide DMXZW3R Discovery agent N.A. Investigative [18]
3-Chloro-4-hydrazino-benzenesulfonamide DMSB5IQ Discovery agent N.A. Investigative [32]
3-Fluoro-4-hydrazino-benzenesulfonamide DMLG69R Discovery agent N.A. Investigative [32]
3-hydroxy-2-methoxybenzaldehyde DMI785L Discovery agent N.A. Investigative [12]
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide DMQ09J8 Discovery agent N.A. Investigative [38]
3-Mercuri-4-Aminobenzenesulfonamide DMX3ANZ Discovery agent N.A. Investigative [19]
3-Nitro-benzenesulfonamide DMAY4OZ Discovery agent N.A. Investigative [39]
3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide DM43CIK Discovery agent N.A. Investigative [40]
3-phenylprop-1-enylboronic acid DMIJN9E Discovery agent N.A. Investigative [41]
4,4'-thiodipyridine-3-sulfonamide DM0K5JM Discovery agent N.A. Investigative [42]
4,6-Dinitro salicylic acid DMIJ4VZ Discovery agent N.A. Investigative [43]
4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide DM5EP3V Discovery agent N.A. Investigative [36]
4-((benzylideneamino)methyl)benzenesulfonamide DM6R43J Discovery agent N.A. Investigative [31]
4-(2-AMINOETHYL)BENZENESULFONAMIDE DMEK6WX Discovery agent N.A. Investigative [5], [44]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide DMWG706 Discovery agent N.A. Investigative [28]
4-(2-Hydroxy-ethyl)-benzenesulfonamide DM1C5U6 Discovery agent N.A. Investigative [45]
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide DME6DHX Discovery agent N.A. Investigative [42]
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide DMZ62L3 Discovery agent N.A. Investigative [46]
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide DM9GOTA Discovery agent N.A. Investigative [46]
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide DMCOD4N Discovery agent N.A. Investigative [46]
4-(2-Phenylacetamido)benzenesulfonamide DMFYR6H Discovery agent N.A. Investigative [46]
4-(2-Phenylacetamidoethyl)benzenesulfonamide DM1JL03 Discovery agent N.A. Investigative [46]
4-(2-Phenylacetamidomethyl)benzenesulfonamide DMDYHXE Discovery agent N.A. Investigative [46]
4-(2-Propynylthio)pyridine-3-sulfonamide DMT9RAC Discovery agent N.A. Investigative [42]
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide DM9LKMP Discovery agent N.A. Investigative [46]
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide DMD6AYQ Discovery agent N.A. Investigative [46]
4-(4-Cyanophenoxy)-3-pyridinesulfonamide DMNEAJH Discovery agent N.A. Investigative [42]
4-(4-Fluorophenoxy)-3-pyridinesulfonamide DMRJLAP Discovery agent N.A. Investigative [42]
4-(4-hydroxy-benzylideneamino)-benzenesulfonamide DMNY0I5 Discovery agent N.A. Investigative [31]
4-(4-hydroxybenzylideneamino)benzoic acid DML357W Discovery agent N.A. Investigative [31]
4-(4-tert-butylbenzylideneamino)benzoic acid DMFLH2G Discovery agent N.A. Investigative [31]
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide DMKT20Q Discovery agent N.A. Investigative [42]
4-(Allylamino)-3-pyridinesulfonamide DM6MQCI Discovery agent N.A. Investigative [42]
4-(benzylideneamino)benzenesulfonamide DM03BQD Discovery agent N.A. Investigative [31]
4-(benzylideneamino)benzoic acid DMJM2H1 Discovery agent N.A. Investigative [31]
4-(Carbamolymethylthio)pyridine-3-sulfonamide DM12R4M Discovery agent N.A. Investigative [42]
4-(Cyanomethylthio)pyridine-3-sulfonamide DMZP20H Discovery agent N.A. Investigative [42]
4-(Hydroxymercury)Benzoic Acid DMWJN73 Discovery agent N.A. Investigative [19]
4-(hydroxymethyl)benzenesulfonamide DMR6VWL Discovery agent N.A. Investigative [28]
4-(Methylhydrazino)-3-pyridinesulfonamide DM4BPL1 Discovery agent N.A. Investigative [42]
4-(N-Methyl-hydrazino)-benzenesulfonamide DMADWTI Discovery agent N.A. Investigative [47]
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide DMYCV8E Discovery agent N.A. Investigative [42]
4-(Quinolinoxy)-3-pyridinesulfonamide DMPNXFA Discovery agent N.A. Investigative [42]
4-Amino-3-bromo-benzenesulfonamide DMVUCZK Discovery agent N.A. Investigative [28]
4-Amino-3-chloro-benzenesulfonamide DMERTQ4 Discovery agent N.A. Investigative [28]
4-Amino-3-fluoro-benzenesulfonamide DMIQ3VR Discovery agent N.A. Investigative [45]
4-Amino-3-iodo-benzenesulfonamide DMCOYHR Discovery agent N.A. Investigative [28]
4-amino-6-chlorobenzene-1,3-disulfonamide DMIWGZS Discovery agent N.A. Investigative [45]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide DMJZNX6 Discovery agent N.A. Investigative [28]
4-azidobenzenesulfonamide DM7EQ06 Discovery agent N.A. Investigative [48]
4-Benzenesulfonylamino-benzenesulfonamide DMC7HKA Discovery agent N.A. Investigative [25]
4-Benzythiopyridine-3-sulfonamide DMI1EFY Discovery agent N.A. Investigative [42]
4-bromophenylboronic acid DM2YN37 Discovery agent N.A. Investigative [41]
4-butylphenylboronic acid DMD9FZW Discovery agent N.A. Investigative [41]
4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide DM2UYCS Discovery agent N.A. Investigative [26]
4-CYANOPHENOL DMN12EX Discovery agent N.A. Investigative [8]
4-Ethoxy-3-pyridinesulfonamide DM8WAOR Discovery agent N.A. Investigative [42]
4-ethynyl benzene sulfonamide DMIF1D6 Discovery agent N.A. Investigative [49]
4-Flourobenzenesulfonamide DMNDS19 Discovery agent N.A. Investigative [19]
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide DMGBKN7 Discovery agent N.A. Investigative [21]
4-Hydrazino-3-pyridinesulfonamide DMSZMQU Discovery agent N.A. Investigative [42]
4-Hydrazino-benzenesulfonamide DM49B18 Discovery agent N.A. Investigative [50]
4-Hydrazinocarbonyl-benzenesulfonamide DM8PBEJ Discovery agent N.A. Investigative [32]
4-isothiocyanatobenzenesulfonamide DMBK67H Discovery agent N.A. Investigative [51]
4-Methanesulfonylamino-benzenesulfonamide DMPH4C8 Discovery agent N.A. Investigative [25]
4-Methoxy-3-pyridinesulfonamide DMJIX7H Discovery agent N.A. Investigative [42]
4-methoxyphenylboronic acid DMP5YFQ Discovery agent N.A. Investigative [41]
4-methoxyphenylsulfamide DMVW8KN Discovery agent N.A. Investigative [17]
4-Methylamino-benzenesulfonamide DM5XMI9 Discovery agent N.A. Investigative [47]
4-Methylimidazole DM45N6U Discovery agent N.A. Investigative [29]
4-methylphenyl-difluoromethanesulfonamide DMR5NLM Discovery agent N.A. Investigative [18]
4-Methylthiopyridine-3-sulfonamide DMEB5XP Discovery agent N.A. Investigative [42]
4-Nitro-benzenesulfonamide DMZY8UW Discovery agent N.A. Investigative [39]
4-nitrophenyl phosphate DMBX4UJ Discovery agent N.A. Investigative [52]
4-nitrophenyl-difluoromethanesulfonamide DM9ETMD Discovery agent N.A. Investigative [18]
4-nitrophenylsulfamide DM47IFL Discovery agent N.A. Investigative [17]
4-phenoxyphenylboronic acid DMMWYI9 Discovery agent N.A. Investigative [41]
4-Sulfonamide-[1-(4-Aminobutane)]Benzamide DM61CJK Discovery agent N.A. Investigative [19]
4-Thiocyanato-benzenesulfonamide DMUGMVI Discovery agent N.A. Investigative [39]
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide DMH3UPO Discovery agent N.A. Investigative [46]
4-[2-(2-Thienyl)acetamido]benzenesulfonamide DMYESXB Discovery agent N.A. Investigative [46]
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide DMGXM9C Discovery agent N.A. Investigative [25]
5-Amino-[1,3,4]thiadiazole-2-thiol DMGA47N Discovery agent N.A. Investigative [53]
5-Chlorosalicylic Acid DMH397E Discovery agent N.A. Investigative [43]
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one DM5RI4H Discovery agent N.A. Investigative [54]
6-(aminomethyl)-2H-chromen-2-one DMJU9TG Discovery agent N.A. Investigative [35]
6-(hydroxymethyl)-2H-chromen-2-one DM5TOX2 Discovery agent N.A. Investigative [35]
6-Amino-benzothiazole-2-sulfonic acid amide DMWPELS Discovery agent N.A. Investigative [55]
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE DMPSOIF Discovery agent N.A. Investigative [5]
6-Hydroxy-benzothiazole-2-sulfonic acid amide DM2B4S5 Discovery agent N.A. Investigative [50]
6-hydroxybenzo[d][1,3]oxathiol-2-one DMDRSNH Discovery agent N.A. Investigative [56]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid DM7WH82 Discovery agent N.A. Investigative [35]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid DMZ6HQL Discovery agent N.A. Investigative [35]
6-Nitro-benzothiazole-2-sulfonic acid amide DMYP7UG Discovery agent N.A. Investigative [39]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [19]
ACETYLSULFANILAMIDE DMG8P24 Discovery agent N.A. Investigative [25]
AL4623 DMHG54F Discovery agent N.A. Investigative [19]
AL5300 DM1QJIV Discovery agent N.A. Investigative [19]
AL5424 DMSD2U1 Discovery agent N.A. Investigative [19]
AL5927 DM624WO Discovery agent N.A. Investigative [19]
AL6528 DM1JIVR Discovery agent N.A. Investigative [19]
Al7089a DMTXPJI Discovery agent N.A. Investigative [19]
AL7099A DMRI08C Discovery agent N.A. Investigative [29]
AL7182 DMG2D4S Discovery agent N.A. Investigative [19]
Allyl 4-(aminosulfonyl)benzoate DMYNKLR Discovery agent N.A. Investigative [24]
Aminobenzolamide derivative DMWYS0Z Discovery agent N.A. Investigative [57]
Azide DM5XZYB Discovery agent N.A. Investigative [16]
BENZOLAMIDE DME5QPX Discovery agent N.A. Investigative [28]
Benzothiazole-2-sulfonic acid amide DMROP5Q Discovery agent N.A. Investigative [58]
Beta-naphthylboronic acid DMZ8Y67 Discovery agent N.A. Investigative [41]
Biphenyl-4-ylboronic acid DMIHMP5 Discovery agent N.A. Investigative [41]
Carzenide DMVD481 Discovery agent N.A. Investigative [24]
CATECHIN DMY38SB Discovery agent N.A. Investigative [11]
Catechol DML0YEK Discovery agent N.A. Investigative [13]
CL-5343 DM9AFZ3 Solid tumour/cancer 2A00-2F9Z Investigative [59]
Coumarin DM0N8ZM Discovery agent N.A. Investigative [60]
Dansylamide DMQ4L1I Discovery agent N.A. Investigative [19]
Decane-1,10-diyl disulfamate DM1ESVR Discovery agent N.A. Investigative [61]
Decyl sulfamate DMIERWO Discovery agent N.A. Investigative [61]
Di(2,6-di-t-butylphenol) DMO6Z02 Discovery agent N.A. Investigative [12]
Di(2,6-diisopropylphenol) DMG21PZ Discovery agent N.A. Investigative [12]
Di(2,6-dimethylphenol) DMZ3EML Discovery agent N.A. Investigative [12]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [13]
EMATE DMFQX1U Discovery agent N.A. Investigative [62]
ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE DMKJGLO Discovery agent N.A. Investigative [5]
Formic Acid DMNFZC6 Discovery agent N.A. Investigative [19]
GALLICACID DM6Y3A0 Discovery agent N.A. Investigative [13]
HYDROSULFIDE DMO32HN Discovery agent N.A. Investigative [16]
IODIDE DM3FZ6P Discovery agent N.A. Investigative [16]
Mercuribenzoic Acid DMT56ER Discovery agent N.A. Investigative [19]
Methyl 4-(4-hydroxybenzylideneamino)benzoate DMUROGX Discovery agent N.A. Investigative [31]
Methyl 4-(4-tert-butylbenzylideneamino)benzoate DMSBCL6 Discovery agent N.A. Investigative [31]
Methyl Mercury Ion DM6YEW4 Discovery agent N.A. Investigative [19]
MMI270 DM38N2K Discovery agent N.A. Investigative [30]
N-(1-benzofuran-3-ylmethyl)sulfamide DM3WBZP Discovery agent N.A. Investigative [63]
N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE DMUZL3J Discovery agent N.A. Investigative [5]
N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide DM9ATQ6 Discovery agent N.A. Investigative [19]
N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide DM3CZVW Discovery agent N.A. Investigative [19]
N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide DME9HNO Discovery agent N.A. Investigative [19]
N-(4-cyanophenyl)sulfamide DMW8S2D Discovery agent N.A. Investigative [64]
N-(4-Sulfamoyl-phenyl)-benzamide DMZDACT Discovery agent N.A. Investigative [25]
N-(4-Sulfamoyl-phenyl)-butyramide DM3FW9Q Discovery agent N.A. Investigative [25]
N-(4-Sulfamoyl-phenyl)-isobutyramide DMJCXYQ Discovery agent N.A. Investigative [25]
N-(4-Sulfamoyl-phenyl)-propionamide DM7MHQD Discovery agent N.A. Investigative [25]
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide DM7QX03 Discovery agent N.A. Investigative [65]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide DMNQDLC Discovery agent N.A. Investigative [66]
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide DMSQEXP Discovery agent N.A. Investigative [53]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide DMA21WB Discovery agent N.A. Investigative [66]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide DM5E7OC Discovery agent N.A. Investigative [66]
N-(pentafluorophenyl)sulfamide DME45J8 Discovery agent N.A. Investigative [64]
N-(phosphonacetyl)-L-aspartate DMGHQJ8 Discovery agent N.A. Investigative [67]
N-1,3,4-thiadiazol-2-ylsulfamide DMJ10WH Discovery agent N.A. Investigative [66]
N-Benzyl-4-Sulfamoyl-Benzamide DMCIJU0 Discovery agent N.A. Investigative [19]
N-hydroxysulfamide DMTDBMU Discovery agent N.A. Investigative [68]
N-hydroxysulfonamides DMJBC03 Discovery agent N.A. Investigative [69]
N-propynyl amidebenzenesulphonide DMWTPJH Discovery agent N.A. Investigative [70]
N-[(4-bromo-1-benzothien-3-yl)methyl]sulfamide DMLTYPS Discovery agent N.A. Investigative [63]
N-[(5-chloro-1-benzothien-3-yl)methyl]sulfamide DMYJHRV Discovery agent N.A. Investigative [63]
N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide DMM7T13 Discovery agent N.A. Investigative [19]
N-[4-(trifluoromethyl)phenyl]sulfamide DMMX65T Discovery agent N.A. Investigative [64]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMSI4PE Discovery agent N.A. Investigative [66]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMXLJGR Discovery agent N.A. Investigative [66]
N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE DMX4QKU Discovery agent N.A. Investigative [5]
Nitrate DMVFB93 Discovery agent N.A. Investigative [16]
NSC-654077 DMW3QAK Discovery agent N.A. Investigative [33]
Octane-1,8-diyl disulfamate DMBQMGH Discovery agent N.A. Investigative [61]
Octyl sulfamate DM40ZCA Discovery agent N.A. Investigative [61]
P-Coumaric Acid DMGJSVD Discovery agent N.A. Investigative [13]
P-toluenesulfonamide DMPEKTO Discovery agent N.A. Investigative [28]
P-tolylboronic acid DM8MZF4 Discovery agent N.A. Investigative [41]
Paraoxon DMN4ZKC Discovery agent N.A. Investigative [52]
Pentane-1,5-diamine DMVPZG9 Discovery agent N.A. Investigative [71]
Pentanoic acid (4-sulfamoyl-phenyl)-amide DMAZ07T Discovery agent N.A. Investigative [25]
Phenethylboronic acid DMPDVG2 Discovery agent N.A. Investigative [41]
Phenoxyarsonous acid DMZJO5V Discovery agent N.A. Investigative [16]
Phenyl Boronic acid DMFZH49 Discovery agent N.A. Investigative [16]
Phenyl-phosphonic acid DMYMNBL Discovery agent N.A. Investigative [67]
PHENYLDIFLUOROMETHANESULFONAMIDE DME75VC Discovery agent N.A. Investigative [18]
PHENYLMETHANESULFONAMIDE DMGLDFI Discovery agent N.A. Investigative [18]
PHENYLSULFAMATE DMRLFJV Discovery agent N.A. Investigative [17]
PHENYLSULFAMIDE DMRTHW1 Discovery agent N.A. Investigative [17]
PRONTOCIL DMIUV25 Discovery agent N.A. Investigative [36]
Prop-2-ynyl 4-sulfamoylbenzoate DM8O41M Discovery agent N.A. Investigative [70]
Quinoline-8-sulfonamide DMTPFLU Discovery agent N.A. Investigative [21]
Resorcinol DMM37C0 Discovery agent N.A. Investigative [8]
Saccharin DMRA736 Discovery agent N.A. Investigative [45]
Sodium 2,3,5,6-tetrafluorobenzoate DMSRM49 Discovery agent N.A. Investigative [72]
SODIUM PERFLUOROHEXANESULFONAMIDE DMESHV2 Discovery agent N.A. Investigative [73]
Sodium trithiocarbonate DM6WYGC Discovery agent N.A. Investigative [74]
SULFAMATE DMF1589 Discovery agent N.A. Investigative [16]
Sulfamic acid 12-sulfamoyloxy-dodecyl ester DM9XNSK Discovery agent N.A. Investigative [75]
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester DM7VBSY Discovery agent N.A. Investigative [75]
Sulfamic acid 3-sulfamoyloxy-phenyl ester DMA0MEV Discovery agent N.A. Investigative [75]
Sulfamic acid 4-sulfamoyloxy-butyl ester DMQZGNJ Discovery agent N.A. Investigative [75]
Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester DMFJR0S Discovery agent N.A. Investigative [75]
Sulfamic acid 6-sulfamoyloxy-hexyl ester DMT3U2D Discovery agent N.A. Investigative [75]
Sulfamic acid 7-sulfamoyloxy-heptyl ester DMVWEN3 Discovery agent N.A. Investigative [75]
Sulfamic acid benzo[1,3]dioxol-2-ylmethyl ester DMFVQYI Discovery agent N.A. Investigative [76]
Sulfamic acid chroman-2-ylmethyl ester DMN0Q71 Discovery agent N.A. Investigative [76]
Syringic Acid DM802V7 Discovery agent N.A. Investigative [13]
Thioureido sulfonamide DM8WYEM Discovery agent N.A. Investigative [77]
Trecadrine DMDX0VI Discovery agent N.A. Investigative [78]
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⏷ Show the Full List of 259 Investigative Drug(s)

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Breast cancer 2C82 Breast tissue 7.95E-08 0.52 0.33
Rheumatoid arthritis FA20 Synovial tissue 4.38E-01 0.62 0.28
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name Carbonic anhydrase II (CA2) DME Info
Gene Name CA2
1 Investigative Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrophenyl acetate DMHSD8A Discovery agent N.A. Investigative [79]
------------------------------------------------------------------------------------

References

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40 Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273. J Med Chem. 2009 Jul 9;52(13):4063-7.
41 Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5.
42 Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404.
43 In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. Bioorg Med Chem. 2008 Oct 15;16(20):9101-5.
44 Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-media... J Med Chem. 2005 Jul 28;48(15):4834-41.
45 Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503.
46 Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9.
47 Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.
48 Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7.
49 Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. J Med Chem. 2008 Mar 27;51(6):1945-53.
50 Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54.
51 Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library. J Med Chem. 2004 Oct 7;47(21):5224-9.
52 Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12.
53 Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-th... Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52.
54 A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. Bioorg Med Chem. 2010 Jun 15;18(12):4468-74.
55 Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides co... J Med Chem. 1999 Jul 15;42(14):2641-50.
56 Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors Bioorg Med Chem Lett. 2008 Jul 15;18(14):3938-41.
57 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides d... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5775-80.
58 Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6.
59 Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide. Eur J Med Chem. 2010 Nov;45(11):4769-73.
60 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8.
61 Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8.
62 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006 Dec 28;49(26):7683-96.
63 Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into huma... J Med Chem. 2009 Dec 10;52(23):7528-36.
64 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8.
65 Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity. Bioorg Med Chem. 2010 Jul 15;18(14):5081-9.
66 Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5.
67 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6.
68 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
69 Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents. J Enzyme Inhib. 1998 Jul;13(4):267-84.
70 A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem. 2006 Nov 2;49(22):6539-48.
71 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22.
72 Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with ali... Bioorg Med Chem. 2009 Apr 1;17(7):2654-7.
73 Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase. Eur J Med Chem. 2010 Mar;45(3):1225-9.
74 Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7.
75 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.
76 Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem. 2005 Mar 24;48(6):1941-7.
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78 Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV. J Enzyme Inhib. 1997 Aug;12(3):175-90.
79 Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds. J Biomol Screen. 2006 Oct;11(7):782-91.