Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4JG0B)

Drug Name
DA-3607 Drug Info
Synonyms Ad-stTRAIL; TRAIL adenoviral gene therapy (cancer), Dong-A
Indication
Disease Entry ICD 11 Status REF
Brain cancer 2A00 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DM4JG0B

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TNF related apoptosis inducing ligand (TNFSF10) TTA5MS9 TNF10_HUMAN Binder [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
TNF related apoptosis inducing ligand (TNFSF10) DTT TNFSF10 5.928 7.18 8.754 8.143
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Brain cancer
ICD Disease Classification 2A00
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
TNF related apoptosis inducing ligand (TNFSF10) DTT TNFSF10 4.40E-01 -0.16 -0.18
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026657)
2 Cancer gene therapy using a novel secretable trimeric TRAIL. Gene Ther. 2006 Feb;13(4):330-8.