Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4NEOU)

• Drug Name: 4-(4-Fluoro-benzyl)-piperidine hydrochloride Drug Info
• Synonyms: 4-(4-Fluorobenzyl)piperidine hydrochloride; 92822-03-2; 193357-52-7; C12H17ClFN; CHEMBL1204355; 4-(4-Fluoro-benzyl)-piperidine hydrochloride; 4-(4'-FLUOROBENZYL)PIPERIDINE HYDROCHLORIDE; Piperidine, 4-[(4-fluorophenyl)methyl]-, hydrochloride; 4-(4-FLUOROBENZYL)PIPERIDINE HCL; AK134910; 4-[(4-fluorophenyl)methyl]piperidine Hydrochloride; 4-(4-FLUOROBENZYL)PIPERIDINE HYDROCHLORIDE Salt; SCHEMBL4247331; KS-00000DOL; CTK7C0359; DTXSID30588780; MolPort-001-778-599; OJKWWANXBGLGQN-UHFFFAOYSA-N; 4NPA-Q05-1; ZX-AV000292; ZX-CM003409

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 17039492
  CAS Number: CAS 193357-52-7
  TTD Drug ID: DM4NEOU

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2A receptor (HTR2A)	DTT	HTR2A	1.68E-01	-0.3	-0.14
5-HT 2A receptor (HTR2A)	DTT	HTR2A	5.59E-01	0.15	0.21

References

• [1] Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. J Med Chem. 1992 Dec 25;35(26):4903-10.