Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4R2EX)

Drug Name

8-acetyl-7-(benzyloxy)-2H-chromen-2-one Drug Info

Synonyms

CHEMBL1290111; 65535-49-1; 8-acetyl-7-(benzyloxy)-2H-chromen-2-one; SCHEMBL7518570; CTK1J6469; DTXSID60555920; BDBM50332028; 8-Acetyl-7-(benzyloxy)-2H-1-benzopyran-2-one; 2H-1-Benzopyran-2-one, 8-acetyl-7-(phenylmethoxy)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 14101447
CAS Number: CAS 65535-49-1
TTD Drug ID: DM4R2EX

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase IX (CA-IX)	DTT	CA9	6.08E-15	2.8	7.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8.