Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT2LVK8)

• DTT Name: Carbonic anhydrase IX (CA-IX)
• Synonyms: Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX
• Gene Name: CA9
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Alpha-carbonic anhydrase
• UniProt ID: CAH9_HUMAN
• TTD ID: T64567
• EC Number: EC 4.2.1.1
• Sequence:
  MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
  GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
  DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
  ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
  VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
  EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
  DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
  GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
• Function: Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Reversible hydration of carbon dioxide.
• KEGG Pathway: Nitrogen metabolism (hsa00910)
• Reactome Pathway:
  Reversible hydration of carbon dioxide (R-HSA-1475029)
  Regulation of gene expression by Hypoxia-inducible Factor (R-HSA-1234158)

Molecular Interaction Atlas (MIA) of This DTT

9 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[2]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[3]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[2]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[4]
Girentuximab I-124	DMG3O2Z	Renal cell carcinoma	2C90	Phase 2	[5]
INDISULAM	DM9SX6Y	Lymphoma	2A80-2A86	Phase 2	[6]
90Y-cG250	DMJR6TC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
BAY 79-4620	DM14XQN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[9]

6 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[3]
PMID30074415-Compound-12	DM7K3A0	N. A.	N. A.	Patented	[10]
PMID30074415-Compound-GS3	DM2G8DN	N. A.	N. A.	Patented	[10]
Sulfonamide derivative 12	DMXEL56	N. A.	N. A.	Patented	[10]
Sulfonamide-thiadiazole derivative 1	DMP9Z34	N. A.	N. A.	Patented	[10]
Sulfonamide-thiadiazole derivative 2	DMZAE78	N. A.	N. A.	Patented	[10]

2 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CA9-ADC	DMSTN6W	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[8]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[11]

168 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(2-bromophenyl)difluoromethanesulfonamide	DMFX9H8	Discovery agent	N.A.	Investigative	[12]
(4-bromophenyl)difluoromethanesulfonamide	DMOCYZJ	Discovery agent	N.A.	Investigative	[12]
(4-sulfamoylphenylethylthioureido)fluorescein	DMGCZOI	Discovery agent	N.A.	Investigative	[13]
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide	DMNHGVD	Discovery agent	N.A.	Investigative	[14]
1,4-phenylene disulfamate	DMEDBO2	Discovery agent	N.A.	Investigative	[15]
1-(3,4-dichlorophenyl)-3-hydroxyurea	DMVOJ7K	Discovery agent	N.A.	Investigative	[16]
1-acetamido-5-sulfonamidoindane	DM92ZCU	Discovery agent	N.A.	Investigative	[17]
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide	DMUXSH5	Discovery agent	N.A.	Investigative	[14]
1-cyclohexylamido-5-sulfonamidoindane	DMFPQME	Discovery agent	N.A.	Investigative	[17]
1-pentafluorophenylamido-5-sulfonamidoindane	DM9PNTQ	Discovery agent	N.A.	Investigative	[17]
1-valproylamido-5-sulfonamidoindane	DM9ZRU2	Discovery agent	N.A.	Investigative	[17]
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide	DMG4ITB	Discovery agent	N.A.	Investigative	[18]
2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide	DMATB8H	Discovery agent	N.A.	Investigative	[18]
2,4-Disulfamyltrifluoromethylaniline	DM2AW0Z	Discovery agent	N.A.	Investigative	[19]
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide	DM1JKWL	Discovery agent	N.A.	Investigative	[20]
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide	DMFGQ7K	Discovery agent	N.A.	Investigative	[20]
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide	DMRADWB	Discovery agent	N.A.	Investigative	[20]
2-(benzyloxyamino)-N-hydroxy-3-methylpentanamide	DMSNCOW	Discovery agent	N.A.	Investigative	[20]
2-(benzyloxyamino)-N-hydroxyacetamide	DMHZJXG	Discovery agent	N.A.	Investigative	[20]
2-(benzyloxyamino)-N-hydroxyhexanamide	DMOUKTH	Discovery agent	N.A.	Investigative	[20]
2-(N''-Acetyl-hydrazino)-benzenesulfonamide	DMHYKR8	Discovery agent	N.A.	Investigative	[21]
2-acetamido-5-sulfonamidoindane	DMPKBVR	Discovery agent	N.A.	Investigative	[17]
2-Amino-benzenesulfonamide	DMEMANH	Discovery agent	N.A.	Investigative	[19]
2-butylamido-5-sulfonamidoindane	DML9MCU	Discovery agent	N.A.	Investigative	[17]
2-cyclohexylamido-5-sulfonamidoindane	DMFBD3K	Discovery agent	N.A.	Investigative	[17]
2-ethylamido-5-sulfonamidoindane	DMDY3JQ	Discovery agent	N.A.	Investigative	[17]
2-Hydrazinocarbonyl-benzenesulfonamide	DMG78U2	Discovery agent	N.A.	Investigative	[21]
2-hydrazinylbenzenesulfonamide	DMCNXZM	Discovery agent	N.A.	Investigative	[19]
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide	DMXEUDM	Discovery agent	N.A.	Investigative	[13]
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide	DMDTRZ2	Discovery agent	N.A.	Investigative	[22]
2-nonylamido-5-sulfonamidoindane	DMOGWIK	Discovery agent	N.A.	Investigative	[17]
2-oxo-2H-chromene-3-carboxylic acid	DMFN769	Discovery agent	N.A.	Investigative	[23]
2-oxo-2H-thiochromene-3-carboxylic acid	DMZTCOM	Discovery agent	N.A.	Investigative	[23]
2-pentafluorophenylamido-5-sulfonamidoindane	DMZ9NCA	Discovery agent	N.A.	Investigative	[17]
2-propylamido-5-sulfonamidoindane	DMG0I25	Discovery agent	N.A.	Investigative	[17]
2-Sulfamoyl-benzoic acid methyl ester	DMAO7DS	Discovery agent	N.A.	Investigative	[21]
2-valproylamido-5-sulfonamidoindane	DM8XSE3	Discovery agent	N.A.	Investigative	[17]
3-((4-aminophenyl)diazenyl)benzenesulfonamide	DM37X04	Discovery agent	N.A.	Investigative	[24]
3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide	DMAPZQW	Discovery agent	N.A.	Investigative	[24]
3-(3-Phenyl-ureido)-benzenesulfonamide	DM314ZE	Discovery agent	N.A.	Investigative	[18]
3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide	DM18MOH	Discovery agent	N.A.	Investigative	[24]
3-Amino-benzenesulfonamide	DME0TNA	Discovery agent	N.A.	Investigative	[25]
3-bromophenyl-difluoromethanesulfonamide	DMXZW3R	Discovery agent	N.A.	Investigative	[12]
3-Chloro-4-hydrazino-benzenesulfonamide	DMSB5IQ	Discovery agent	N.A.	Investigative	[21]
3-Fluoro-4-hydrazino-benzenesulfonamide	DMLG69R	Discovery agent	N.A.	Investigative	[21]
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide	DMQ09J8	Discovery agent	N.A.	Investigative	[26]
4,4'-thiodipyridine-3-sulfonamide	DM0K5JM	Discovery agent	N.A.	Investigative	[27]
4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide	DM5EP3V	Discovery agent	N.A.	Investigative	[24]
4-(2-AMINOETHYL)BENZENESULFONAMIDE	DMEK6WX	Discovery agent	N.A.	Investigative	[28]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide	DMWG706	Discovery agent	N.A.	Investigative	[19]
4-(2-Hydroxy-ethyl)-benzenesulfonamide	DM1C5U6	Discovery agent	N.A.	Investigative	[19]
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide	DME6DHX	Discovery agent	N.A.	Investigative	[27]
4-(2-Propynylthio)pyridine-3-sulfonamide	DMT9RAC	Discovery agent	N.A.	Investigative	[27]
4-(4'-N-Methylphenyl)diazenylbenzenesulfonamide	DMGVNE3	Discovery agent	N.A.	Investigative	[24]
4-(4-Cyanophenoxy)-3-pyridinesulfonamide	DMNEAJH	Discovery agent	N.A.	Investigative	[27]
4-(4-Fluorophenoxy)-3-pyridinesulfonamide	DMRJLAP	Discovery agent	N.A.	Investigative	[27]
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide	DMKT20Q	Discovery agent	N.A.	Investigative	[27]
4-(Allylamino)-3-pyridinesulfonamide	DM6MQCI	Discovery agent	N.A.	Investigative	[27]
4-(Carbamolymethylthio)pyridine-3-sulfonamide	DM12R4M	Discovery agent	N.A.	Investigative	[27]
4-(Cyanomethylthio)pyridine-3-sulfonamide	DMZP20H	Discovery agent	N.A.	Investigative	[27]
4-(hydroxymethyl)benzenesulfonamide	DMR6VWL	Discovery agent	N.A.	Investigative	[19]
4-(Methylhydrazino)-3-pyridinesulfonamide	DM4BPL1	Discovery agent	N.A.	Investigative	[27]
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide	DMYCV8E	Discovery agent	N.A.	Investigative	[27]
4-(Quinolinoxy)-3-pyridinesulfonamide	DMPNXFA	Discovery agent	N.A.	Investigative	[27]
4-Amino-3-bromo-benzenesulfonamide	DMVUCZK	Discovery agent	N.A.	Investigative	[19]
4-Amino-3-chloro-benzenesulfonamide	DMERTQ4	Discovery agent	N.A.	Investigative	[19]
4-Amino-3-fluoro-benzenesulfonamide	DMIQ3VR	Discovery agent	N.A.	Investigative	[19]
4-Amino-3-iodo-benzenesulfonamide	DMCOYHR	Discovery agent	N.A.	Investigative	[19]
4-amino-6-chlorobenzene-1,3-disulfonamide	DMIWGZS	Discovery agent	N.A.	Investigative	[19]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	DMJZNX6	Discovery agent	N.A.	Investigative	[19]
4-azidobenzenesulfonamide	DM7EQ06	Discovery agent	N.A.	Investigative	[29]
4-Benzenesulfonylamino-benzenesulfonamide	DMC7HKA	Discovery agent	N.A.	Investigative	[18]
4-Benzythiopyridine-3-sulfonamide	DMI1EFY	Discovery agent	N.A.	Investigative	[27]
4-Ethoxy-3-pyridinesulfonamide	DM8WAOR	Discovery agent	N.A.	Investigative	[27]
4-ethynyl benzene sulfonamide	DMIF1D6	Discovery agent	N.A.	Investigative	[30]
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide	DMGBKN7	Discovery agent	N.A.	Investigative	[15]
4-Hydrazino-3-pyridinesulfonamide	DMSZMQU	Discovery agent	N.A.	Investigative	[27]
4-Hydrazino-benzenesulfonamide	DM49B18	Discovery agent	N.A.	Investigative	[19]
4-Hydrazinocarbonyl-benzenesulfonamide	DM8PBEJ	Discovery agent	N.A.	Investigative	[21]
4-Methanesulfonylamino-benzenesulfonamide	DMPH4C8	Discovery agent	N.A.	Investigative	[18]
4-Methoxy-3-pyridinesulfonamide	DMJIX7H	Discovery agent	N.A.	Investigative	[27]
4-methylphenyl-difluoromethanesulfonamide	DMR5NLM	Discovery agent	N.A.	Investigative	[12]
4-Methylthiopyridine-3-sulfonamide	DMEB5XP	Discovery agent	N.A.	Investigative	[27]
4-nitrophenyl-difluoromethanesulfonamide	DM9ETMD	Discovery agent	N.A.	Investigative	[12]
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide	DMGXM9C	Discovery agent	N.A.	Investigative	[18]
5-Amino-[1,3,4]thiadiazole-2-thiol	DMGA47N	Discovery agent	N.A.	Investigative	[31]
6-(aminomethyl)-2H-chromen-2-one	DMJU9TG	Discovery agent	N.A.	Investigative	[23]
6-(hydroxymethyl)-2H-chromen-2-one	DM5TOX2	Discovery agent	N.A.	Investigative	[23]
6-Acetyl-7-ethoxy-2H-chromen-2-one	DMERKGH	Discovery agent	N.A.	Investigative	[32]
6-Acetyl-7-hydroxy-2H-chromen-2-one	DM1K0E2	Discovery agent	N.A.	Investigative	[32]
6-acetyl-7-methoxy-2H-chromen-2-one	DMXOB2K	Discovery agent	N.A.	Investigative	[32]
6-acetyl-7-propoxy-2H-chromen-2-one	DMCG8BJ	Discovery agent	N.A.	Investigative	[32]
6-Hydroxy-benzothiazole-2-sulfonic acid amide	DM2B4S5	Discovery agent	N.A.	Investigative	[19]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid	DM7WH82	Discovery agent	N.A.	Investigative	[23]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid	DMZ6HQL	Discovery agent	N.A.	Investigative	[23]
7-(benzyloxy)-2H-chromen-2-one	DMTKFPW	Discovery agent	N.A.	Investigative	[23]
7-butoxy-2H-chromen-2-one	DM78C5A	Discovery agent	N.A.	Investigative	[23]
7-ethoxy-8-propionyl-2H-chromen-2-one	DMYJBPI	Discovery agent	N.A.	Investigative	[32]
7-hydroxy-6-propionyl-2H-chromen-2-one	DMQ3RVK	Discovery agent	N.A.	Investigative	[32]
7-hydroxy-8-propionyl-2H-chromen-2-one	DMFKSMW	Discovery agent	N.A.	Investigative	[32]
7-hydroxycoumarin	DMTMNO7	Discovery agent	N.A.	Investigative	[32]
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid	DMJITU0	Discovery agent	N.A.	Investigative	[23]
7-methoxy-8-propionyl-2H-chromen-2-one	DMH0UVE	Discovery agent	N.A.	Investigative	[32]
7-phenethoxy-2H-chromen-2-one	DM8Q267	Discovery agent	N.A.	Investigative	[23]
7-propoxy-2H-chromen-2-one	DMD5CB6	Discovery agent	N.A.	Investigative	[23]
8-acetyl-7-(benzyloxy)-2H-chromen-2-one	DM4R2EX	Discovery agent	N.A.	Investigative	[32]
8-acetyl-7-butoxy-2H-chromen-2-one	DMCTWBL	Discovery agent	N.A.	Investigative	[32]
8-acetyl-7-ethoxy-2H-chromen-2-one	DMDV8UT	Discovery agent	N.A.	Investigative	[32]
8-Acetyl-7-hydroxy-2H-chromen-2-one	DMAMJW2	Discovery agent	N.A.	Investigative	[32]
8-acetyl-7-methoxy-2H-chromen-2-one	DMZSJRC	Discovery agent	N.A.	Investigative	[32]
8-acetyl-7-propoxy-2H-chromen-2-one	DMGRK3V	Discovery agent	N.A.	Investigative	[32]
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid	DMHCWY8	Discovery agent	N.A.	Investigative	[23]
8-Propionyl-7-propoxy-2H-chromen-2-one	DMKWYJX	Discovery agent	N.A.	Investigative	[32]
ACETYLSULFANILAMIDE	DMG8P24	Discovery agent	N.A.	Investigative	[18]
Aminobenzolamide derivative	DMWYS0Z	Discovery agent	N.A.	Investigative	[33]
Azide	DM5XZYB	Discovery agent	N.A.	Investigative	[34]
BENZOLAMIDE	DME5QPX	Discovery agent	N.A.	Investigative	[19]
BICARBONATE	DMT5E36	Discovery agent	N.A.	Investigative	[9]
Carzenide	DMVD481	Discovery agent	N.A.	Investigative	[19]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[2]
CL-5343	DM9AFZ3	Solid tumour/cancer	2A00-2F9Z	Investigative	[35]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[23]
Decane-1,10-diyl disulfamate	DM1ESVR	Discovery agent	N.A.	Investigative	[36]
Decyl sulfamate	DMIERWO	Discovery agent	N.A.	Investigative	[36]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[3]
ETHOXYCOUMARIN	DMSKU4M	Discovery agent	N.A.	Investigative	[23]
Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate	DMWIB0V	Discovery agent	N.A.	Investigative	[23]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[3]
HERNIARIN	DM9UASM	Discovery agent	N.A.	Investigative	[23]
Hexane-1,6-diamine	DMSHF0K	Discovery agent	N.A.	Investigative	[11]
HYDROSULFIDE	DMO32HN	Discovery agent	N.A.	Investigative	[34]
MMI270	DM38N2K	Discovery agent	N.A.	Investigative	[20]
N-(4-cyanophenyl)sulfamide	DMW8S2D	Discovery agent	N.A.	Investigative	[37]
N-(4-Sulfamoyl-phenyl)-benzamide	DMZDACT	Discovery agent	N.A.	Investigative	[18]
N-(4-Sulfamoyl-phenyl)-butyramide	DM3FW9Q	Discovery agent	N.A.	Investigative	[18]
N-(4-Sulfamoyl-phenyl)-isobutyramide	DMJCXYQ	Discovery agent	N.A.	Investigative	[18]
N-(4-Sulfamoyl-phenyl)-propionamide	DM7MHQD	Discovery agent	N.A.	Investigative	[18]
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide	DM7QX03	Discovery agent	N.A.	Investigative	[38]
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide	DMSQEXP	Discovery agent	N.A.	Investigative	[31]
N-(pentafluorophenyl)sulfamide	DME45J8	Discovery agent	N.A.	Investigative	[37]
N-hydroxysulfamide	DMTDBMU	Discovery agent	N.A.	Investigative	[39]
N-propynyl amidebenzenesulphonide	DMWTPJH	Discovery agent	N.A.	Investigative	[40]
N1-(2-aminoethyl)ethane-1,2-diamine	DM6HM5S	Discovery agent	N.A.	Investigative	[11]
N1-(naphthalen-1-yl)ethane-1,2-diamine	DMYGCSV	Discovery agent	N.A.	Investigative	[11]
NSC-654077	DMW3QAK	Discovery agent	N.A.	Investigative	[13]
Octane-1,8-diyl disulfamate	DMBQMGH	Discovery agent	N.A.	Investigative	[36]
Octyl sulfamate	DM40ZCA	Discovery agent	N.A.	Investigative	[36]
P-Coumaric Acid	DMGJSVD	Discovery agent	N.A.	Investigative	[3]
P-toluenesulfonamide	DMPEKTO	Discovery agent	N.A.	Investigative	[19]
Pentane-1,5-diamine	DMVPZG9	Discovery agent	N.A.	Investigative	[11]
Pentanoic acid (4-sulfamoyl-phenyl)-amide	DMAZ07T	Discovery agent	N.A.	Investigative	[18]
PHENYLDIFLUOROMETHANESULFONAMIDE	DME75VC	Discovery agent	N.A.	Investigative	[12]
PHENYLMETHANESULFONAMIDE	DMGLDFI	Discovery agent	N.A.	Investigative	[12]
PHENYLSULFAMATE	DMRLFJV	Discovery agent	N.A.	Investigative	[12]
Prop-2-ynyl 4-sulfamoylbenzoate	DM8O41M	Discovery agent	N.A.	Investigative	[40]
Quinoline-8-sulfonamide	DMTPFLU	Discovery agent	N.A.	Investigative	[15]
SACCHARIN	DMRA736	Discovery agent	N.A.	Investigative	[41]
Sodium N-methylphenylaminomethanesulfonate	DMBVQI4	Discovery agent	N.A.	Investigative	[24]
Sodium phenylaminomethanesulfonate	DMJ7I4U	Discovery agent	N.A.	Investigative	[24]
SULFAMATE	DMF1589	Discovery agent	N.A.	Investigative	[9]
Sulfamic acid 12-sulfamoyloxy-dodecyl ester	DM9XNSK	Discovery agent	N.A.	Investigative	[42]
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester	DM7VBSY	Discovery agent	N.A.	Investigative	[42]
Sulfamic acid 3-sulfamoyloxy-phenyl ester	DMA0MEV	Discovery agent	N.A.	Investigative	[42]
Sulfamic acid 4-sulfamoyloxy-butyl ester	DMQZGNJ	Discovery agent	N.A.	Investigative	[42]
Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester	DMFJR0S	Discovery agent	N.A.	Investigative	[42]
Sulfamic acid 6-sulfamoyloxy-hexyl ester	DMT3U2D	Discovery agent	N.A.	Investigative	[42]
Sulfamic acid 7-sulfamoyloxy-heptyl ester	DMVWEN3	Discovery agent	N.A.	Investigative	[42]
Syringic Acid	DM802V7	Discovery agent	N.A.	Investigative	[3]

Molecular Expression Atlas (MEA) of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Renal cancer	2C82	Kidney	6.08E-15	2.8	7.25
Breast cancer	2C82	Breast tissue	1.12E-10	-0.03	-0.09

References

• [1] Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
• [2] Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
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