Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5BUXZ)

Drug Name

10-Acetyl-1,8-dihydroxy-10H-anthracen-9-one Drug Info

Synonyms

10-Acetyl dithranol; CCRIS 2039; CHEMBL339332; 3022-61-5; 10-Acetyl-1,8-dihydroxy-10H-anthracen-9-one; 9(10H)-Anthracenone, 10-acetyl-1,8-dihydroxy-; 10-Acetylanthraline; AC1MIVB6; SCHEMBL10630399; DTXSID30184322; 1,8-Dihydroxy-10-acetylanthrone; JLVFGQSHNYEUIN-UHFFFAOYSA-N; 1,8-dihydroxy-10-acetyl anthrone; ZINC13606543; BDBM50060870

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3080591
CAS Number: CAS 3022-61-5
TTD Drug ID: DM5BUXZ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80.