Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5F0QY)

Drug Name
IONIS-416858 Drug Info
Synonyms IONIS-FXI-LRx
Indication
Disease Entry ICD 11 Status REF
Thrombosis DB61-GB90 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM5F0QY

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Factor XI messenger RNA (F11 mRNA) TTDM4ZU FA11_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Factor XI messenger RNA (F11 mRNA) DTT F11 8.057 5.368 5.527 5.485
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Thrombosis
ICD Disease Classification DB61-GB90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Factor XI messenger RNA (F11 mRNA) DTT F11 8.24E-01 -3.39E-03 -0.04
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of Ionis Pharmaceuticals.