Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5HPZU)

Drug Name
NOX-H94 Drug Info
Indication
Disease Entry ICD 11 Status REF
Anemia 3A00-3A9Z Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM5HPZU

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hepcidin (HAMP) TTPCG5T HEPC_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Hepcidin (HAMP) DTT HAMP 10.14 3.018 4.372 4.315
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Anemia
ICD Disease Classification 3A00-3A9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Hepcidin (HAMP) DTT HAMP 5.37E-01 0.18 0.47
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood. 2013 Mar 21;121(12):2311-5.