General Information of Drug (ID: DM5L23N)

Drug Name
JNJ-5207852 Drug Info
Synonyms
398473-34-2; JNJ-5207852; UNII-4I9OVB1G7D; JNJ 5207852; 1-[4-(3-piperidinopropoxy)benzyl]piperidine; 4I9OVB1G7D; CHEMBL129542; JNJ 5207852 dihydrochloride; 1-[3-[4-(piperidin-1-ylmethyl)phenoxy]propyl]piperidine; Piperidine, 1-(3-(4-(1-piperidinylmethyl)phenoxy)propyl)-; 1-(3-(4-((Piperidin-1-yl)methyl)phenoxy)propyl)piperidine; 1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piperidine; Piperidine, 1-[3-[4-(1-piperidinylmethyl)phenoxy]propyl]-; 1-(3-{4-[(piperidin-1-yl)methyl]phenoxy}propyl)piperidine; AC1MCCJO
Indication
Disease Entry ICD 11 Status REF
Narcolepsy 7A20 Investigative [1]
Cross-matching ID
PubChem CID
2766326
CAS Number
CAS 398473-34-2
TTD Drug ID
DM5L23N

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H3 receptor (H3R) TT9JNIC HRH3_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Histamine H3 receptor (H3R) DTT HRH3 3.225 3.399 3.17 3.027
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Narcolepsy
ICD Disease Classification 7A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histamine H3 receptor (H3R) DTT HRH3 3.62E-02 -0.09 -0.22
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1256).
2 The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.