Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5LY1H)

Drug Name
Leptin Drug Info
Synonyms Leptin (Alzheimer's disease)
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Investigative [1]
Cross-matching ID
PubChem CID
157010069
TTD Drug ID
DM5LY1H

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leptin receptor (LEPR) TT0HD6V LEPR_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Leptin receptor (LEPR) DTT LEPR 8.131 5.561 5.776 5.3
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Leptin receptor (LEPR) DTT LEPR 5.82E-02 0.05 0.15
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5015).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712).