Details of the Drug

General Information of Drug (ID: DM5LY1H)

Drug Name
Leptin
Synonyms Leptin (Alzheimer's disease)
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Investigative [1]
ADMET Property
Half-life
The concentration or amount of drug in body reduced by one-half in 24.9 +/- 4.4 minutes [2]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Ovarian cancer Not Available RHOA ARH12 ARHA RHO12 OT6YOJ9N [3]
Ovarian cancer Not Available AKT1 OT8H2YY7 [3]
Ovarian cancer Not Available STAT3 OTAAGKYZ [3]
Ovarian cancer Not Available JAK2 OTBIDOOR [3]
Ovarian cancer Not Available PIK3CB PIK3C1 OTO8JQJA [3]
Ovarian cancer Not Available ROCK1 OTSXYVW1 [3]
Reproductive tract disorder Not Available SLC2A2 OTBL2W7R [3]
Reproductive tract disorder Not Available LDHA OTN7K4XB [3]
⏷ Show the Full List of 8 ADR Information of This Drug
Cross-matching ID
PubChem CID
157010069
DrugBank ID
DB05098
TTD ID
D0C6TL

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leptin receptor (LEPR) TT0HD6V LEPR_HUMAN Modulator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
L-lactate dehydrogenase A chain (LDHA) OTN7K4XB LDHA_HUMAN Drug Response [3]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) OTO8JQJA PK3CB_HUMAN Drug Response [3]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Drug Response [3]
Rho-associated protein kinase 1 (ROCK1) OTSXYVW1 ROCK1_HUMAN Drug Response [3]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Drug Response [3]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Drug Response [3]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Drug Response [3]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Drug Response [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Leptin receptor (LEPR) DTT LEPR 5.82E-02 0.05 0.15
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5015).
2 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
3 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712).