Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5PS6K)

Drug Name

Methyl-piperidine compound 1 Drug Info

Synonyms

PMID28627961-Compound-36

Indication

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin E synthase (PTGES)	TTYLQ8V	PTGES_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin E synthase (PTGES)	DTT	PTGES	4.289	5.498	5.489	5.794

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Angiogenesis disorder

ICD Disease Classification

BE2Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin E synthase (PTGES)	DTT	PTGES	7.92E-02	-0.05	-0.24

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004.
2	Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059.