Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5QDK9)

Drug Name

(4-bromo-1H-pyrazol-1-yl)(o-tolyl)methanone Drug Info

Synonyms

(4-bromo-1H-pyrazol-1-yl)(2-methylphenyl)methanone; AC1LDSC9; N-Benzoylpyrazole deriv., 23; CHEMBL245163; ZINC37182; BDBM23715; MolPort-002-118-506; STK059624; AKOS001747311; 4-bromopyrazolyl 2-methylphenyl ketone; MCULE-5811997287; ST033218; (4-bromopyrazol-1-yl)-(2-methylphenyl)methanone; SR-01000524307; SR-01000524307-1; 4-bromo-1-[(2-methylphenyl)carbonyl]-1H-pyrazole

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 674650
TTD Drug ID: DM5QDK9

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neutrophil elastase (NE)	TTPLTSQ	ELNE_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neutrophil elastase (NE)	DTT	ELANE	2.379	2.036	1.379	2.945

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neutrophil elastase (NE)	DTT	ELANE	2.35E-01	-0.55	-0.82

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38.