Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5QS17)

Drug Name

ED1 Drug Info

Synonyms

ethylenediamine scaffold, 10; BDBM31426; ED1; 3-{2'-[{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)sulfamoyl]biphenyl-3-yl}propanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Acute respiratory distress syndrome	CB00	Investigative	[1]
Myocardial reperfusion injury	NB31	Investigative	[1]
Sepsis	1G40-1G41	Investigative	[1]

Cross-matching ID

PubChem CID: 25181318
TTD Drug ID: DM5QS17

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neutrophil elastase (NE)	TTPLTSQ	ELNE_HUMAN	Not Available	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neutrophil elastase (NE)	DTT	ELANE	2.379	2.036	1.379	2.945

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Acute respiratory distress syndrome

ICD Disease Classification

CB00

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neutrophil elastase (NE)	DTT	ELANE	2.35E-01	-0.55	-0.82

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60.