Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5UWH9)

Drug Name

1-Ethyl-3-imidazol-1-ylmethyl-1H-indole Drug Info

Synonyms

CHEMBL115899; 72818-64-5; 1-Ethyl-3-imidazol-1-ylmethyl-1H-indole; SCHEMBL11496228; CTK2G2099; DTXSID10438234; BDBM50022117; ZINC27096766; 1-Ethyl-3-[(1H-imidazol-1-yl)methyl]-1H-indole; 1H-Indole, 1-ethyl-3-(1H-imidazol-1-ylmethyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10331244
CAS Number: CAS 72818-64-5
TTD Drug ID: DM5UWH9

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. J Med Chem. 1986 Mar;29(3):342-6.