Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5VLIE)

Drug Name

1,2,3,4-Tetrahydro-isoquinolin-7-ol Drug Info

Synonyms

1,2,3,4-tetrahydroisoquinolin-7-ol; 30798-64-2; 1,2,3,4-Tetrahydro-isoquinolin-7-ol; 1,2,3,4-Tetrahydro-7-isoquinolinol; 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline; CHEMBL27730; RADQTHXRZJGDQI-UHFFFAOYSA-N; 7-Isoquinolinol, 1,2,3,4-tetrahydro-; 1,2,3,4-Tetrahydro-iosquinoline-7-ol; AC1L9HE2; 7-Hydroxytetrahydroisochinolin; SCHEMBL470826; AC1Q798F; DTXSID40329303; MolPort-005-312-666; ZINC3847389; BDBM50024826; ANW-75301; AKOS006222928; MB05747; RP21285; AC-9597; MCULE-2692939705; KB-74165; KB-64192; BS-13490; AJ-45863; TC-062003

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 419268
CAS Number: CAS 30798-64-2
TTD Drug ID: DM5VLIE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005.