Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5ZEPD)

• Drug Name: SCH79687 Drug Info
• Synonyms: CHEMBL366977; 224585-45-9; SCHEMBL7860131; BDBM86188; DTXSID20430941; SCH 79687; PDSP1_001301; SCH-79687; PDSP2_001285; L018853

Indication

Disease Entry	ICD 11	Status	REF
Central nervous system disease	8A04-8D87	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9801743
  CAS Number: CAS 224585-45-9
  TTD Drug ID: DM5ZEPD

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Antagonist	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histamine H3 receptor (H3R)	DTT	HRH3	3.225	3.399	3.17	3.027

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Central nervous system disease
• ICD Disease Classification: 8A04-8D87

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H3 receptor (H3R)	DTT	HRH3	3.62E-02	-0.09	-0.22

References

• [1] The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.