Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM624WO)

Drug Name

AL5927 Drug Info

Synonyms

AL5927; n-[(4-methoxyphenyl)methyl]2,5-thiophenedesulfonamide; 2-N-[(4-methoxyphenyl)methyl]thiophene-2,5-disulfonamide; N-(4-methoxybenzyl)thiophene-2,5-disulfonamide; AL9; 1bn4; AC1L1HW5; SCHEMBL680127; BDBM11930; 2,5-Thiophenedisulfonamide, N2-[(4-methoxyphenyl)methyl]-; DB03526

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 4316
TTD Drug ID: DM624WO

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.