Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM63O4F)

Drug Name
PURPUROGALLIN Drug Info
Synonyms 3tiy; AC1NQYND; BIDD:ER0545
Cross-matching ID
PubChem CID
135403797
ChEBI ID
CHEBI:8647
CAS Number
CAS 569-77-7
TTD Drug ID
DM63O4F

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bcl-x messenger RNA (BCL2L1 mRNA) TTRE6AX B2CL1_HUMAN Inhibitor [1]
L-selectin (SELL) TT2IYXF LYAM1_HUMAN Inhibitor [2]
P-selectin (SELP) TTE5VG0 LYAM3_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Bcl-x messenger RNA (BCL2L1 mRNA) DTT BCL2L1 4.863 5.664 6.092 5.843
P-selectin (SELP) DTT SELP 7.304 7.427 7.315 7.849
L-selectin (SELL) DTT SELL 6.2 6.209 6.154 5.963
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
P-selectin (SELP) DTT SELP 1.72E-04 1.23 0.86
L-selectin (SELL) DTT SELL 3.40E-07 2.19 1.02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem. 2003 Sep 25;46(20):4259-64.
2 Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem. 2007 Mar 22;50(6):1101-15.