General Information of Drug (ID: DM69UZG)

Drug Name
HPP-851 Drug Info
Synonyms
11-beta HSD-1 (metabolic disorders), High Point; 11-beta HSD-1 (metabolic disorders), TransTech Pharma; 11-beta hydroxysteroid dehydrogenase-1 inhibitors (metabolic disorders), Novo Nordisk; 11-beta hydroxysteroid dehydrogenase-1 inhibitors (metabolic disorders), TransTech Pharma
Indication
Disease Entry ICD 11 Status REF
Metabolic disorder 5C50-5D2Z Preclinical [1]
Cross-matching ID
TTD Drug ID
DM69UZG

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) TTN7BL9 DHI1_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DTT HSD11B1 10.967 5.178 5.865 6.377
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Metabolic disorder
ICD Disease Classification 5C50-5D2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DTT HSD11B1 2.03E-01 -0.01 -0.08
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027759)
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027759)