Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6ARQF)

Drug Name

1-(4-fluorophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info

Synonyms

CHEMBL203640; 1-(4-fluorophenyl)-2-pyrrolidin-1-yl-pentan-1-one; 4-Fluoro-alpha-pvp; FPVP; SCHEMBL4938098; BDBM50182583; 4'-Fluoro-alpha-pyrrolidinopentiophenone; 1-(4-Fluorophenyl)-2-pyrrolizinopentane-1-one; 4-Fluoro-alpha-2-(1-pyrrolidinyl)-valerophenone; 1-(4-fluorophenyl)-2-(1-pyrrolidinyl)-1-pentanone; 2-(Pyrrolidin-1-yl)-1-(4-fluorophenyl)pentan-1-one; 1-Pentanone, 1-(4-fluorophenyl)-2-(1-pyrrolidinyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11322641
CAS Number: CAS 850352-62-4
TTD Drug ID: DM6ARQF

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7
Norepinephrine transporter (NET)	DTT	SLC6A2	2.459	3.426	3.322	3.35

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32.