Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6XC8H)

Drug Name
MSC110 Drug Info
Synonyms Lacnotuzumab
Indication
Disease Entry ICD 11 Status REF
Pigmented villonodular synovitis FA27.1 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DM6XC8H

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Macrophage colony-stimulating factor 1 (CSF1) TT0IQER CSF1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Macrophage colony-stimulating factor 1 (CSF1) DTT CSF1 3.95 4.555 4.542 4.399
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Pigmented villonodular synovitis
ICD Disease Classification FA27.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Macrophage colony-stimulating factor 1 (CSF1) DTT CSF1 6.22E-01 -0.14 -1.29
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes. J Pharmacol Exp Ther. 2019 Jun;369(3):428-442.