Details of the Drug

General Information of Drug (ID: DM6XC8H)

Drug Name
MSC110
Synonyms Lacnotuzumab
Indication
Disease Entry ICD 11 Status REF
Pigmented villonodular synovitis FA27.1 Phase 1 [1]
Drug Type
Antibody
Cross-matching ID
TTD ID
D18QIB

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Macrophage colony-stimulating factor 1 (CSF1) TT0IQER CSF1_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Pigmented villonodular synovitis
ICD Disease Classification FA27.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Macrophage colony-stimulating factor 1 (CSF1) DTT CSF1 6.22E-01 -0.14 -1.29
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes. J Pharmacol Exp Ther. 2019 Jun;369(3):428-442.